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Drug–gut microbiota interactions: implications for neuropharmacology

Overview of attention for article published in British Journal of Pharmacology, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (94th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
2 news outlets
twitter
48 X users
patent
1 patent
facebook
4 Facebook pages

Citations

dimensions_citation
96 Dimensions

Readers on

mendeley
150 Mendeley
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Title
Drug–gut microbiota interactions: implications for neuropharmacology
Published in
British Journal of Pharmacology, June 2018
DOI 10.1111/bph.14366
Pubmed ID
Authors

Jacinta Walsh, Brendan T Griffin, Gerard Clarke, Niall P Hyland

Abstract

The fate and activity of drugs are frequently dictated not only by the host per se but also by the microorganisms present in the gastrointestinal tract. The gut microbiome is known to, both directly and indirectly, affect drug metabolism. More evidence now hints at the impact that drugs can have on the function and composition of the gut microbiome. Both microbiota-mediated alterations in drug metabolism and drug-mediated alterations in the gut microbiome can have beneficial or detrimental effects on the host. Greater insights into the mechanisms driving these reciprocal drug-gut microbiota interactions are needed, to guide the development of microbiome-targeted dietary or pharmacological interventions, with the potential to enhance drug efficacy or reduce drug side-effects. In this review, we explore the relationship between drugs and the gut microbiome, with a specific focus on potential mechanisms underpinning the drug-mediated alterations on the gut microbiome and the potential implications for psychoactive drugs.

X Demographics

X Demographics

The data shown below were collected from the profiles of 48 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 150 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 18 12%
Student > Bachelor 18 12%
Student > Master 16 11%
Student > Ph. D. Student 15 10%
Student > Doctoral Student 11 7%
Other 27 18%
Unknown 45 30%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 13%
Medicine and Dentistry 17 11%
Agricultural and Biological Sciences 15 10%
Pharmacology, Toxicology and Pharmaceutical Science 11 7%
Neuroscience 7 5%
Other 27 18%
Unknown 54 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 47. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 February 2023.
All research outputs
#883,101
of 25,204,906 outputs
Outputs from British Journal of Pharmacology
#172
of 7,688 outputs
Outputs of similar age
#19,092
of 335,892 outputs
Outputs of similar age from British Journal of Pharmacology
#3
of 72 outputs
Altmetric has tracked 25,204,906 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,688 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.0. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,892 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 72 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.