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X Demographics
Mendeley readers
Attention Score in Context
| Title |
The Significance of the Discordant Occurrence of Lens Tumors in Humans versus Other Species
|
|---|---|
| Published in |
Ophthalmology, June 2015
|
| DOI | 10.1016/j.ophtha.2015.05.028 |
| Pubmed ID | |
| Authors |
Daniel M. Albert, Paul O. Phelps, Krishna R. Surapaneni, Bradley A. Thuro, Heather A.D. Potter, Akihiro Ikeda, Leandro B.C. Teixeira, Richard R. Dubielzig |
| Abstract |
The purpose of this study was to determine in which species and under what conditions lens tumors occur. A review of databases of available human and veterinary ocular pathologic material and the previously reported literature. Approximately 18 000 patients who had ocular surgical specimens submitted and studied at the University of Wisconsin School of Medicine and Public Health between 1920 and 2014 and 45 000 ocular veterinary cases from the Comparative Ocular Pathology Laboratory of Wisconsin between 1983 and 2014. Material in 2 major archived collections at the University of Wisconsin medical and veterinary schools were studied for occurrence of lens tumors. Tumor was defined as a new growth of tissue characterized by progressive, uncontrolled proliferation of cells. In addition, cases presented at 3 major eye pathologic societies (Verhoeff-Zimmerman Ophthalmic Pathology Society, Eastern Ophthalmic Pathology Society, and The Armed Forces Institute of Pathology Ophthalmic Alumni Society) from 1975 through 2014 were reviewed. Finally, a careful search of the literature was carried out. Approval from the institutional review board to carry out this study was obtained. The presence of tumors of the lens. The database search and literature review failed to find an example of a lens tumor in humans. In contrast, examples of naturally occurring lens tumors were found in cats, dogs, rabbits, and birds. In the veterinary school database, 4.5% of feline intraocular and adnexal neoplasms (234/5153) were designated as feline ocular posttraumatic sarcoma, a tumor previously demonstrated to be of lens epithelial origin. Similar tumors were seen in rabbit eyes, a bird, and in a dog. All 4 species with lens tumors had a history of either ocular trauma or protracted uveitis. The literature search also revealed cases where lens tumors were induced in zebrafish, rainbow trout, hamsters, and mice by carcinogenic agents (methylcholanthrene, thioacetamide), oncogenic viruses (SV40, HPV-16), and genetic manipulation. Our results suggest that lens tumors do not occur in humans. In contrast, after lens capsule rupture, a lens tumor can occur in other species. We hypothesize that a genetic mechanism exists that prevents lens tumors in humans. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Saudi Arabia | 4 | 19% |
| United States | 4 | 19% |
| United Kingdom | 1 | 5% |
| Algeria | 1 | 5% |
| Unknown | 11 | 52% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 16 | 76% |
| Practitioners (doctors, other healthcare professionals) | 4 | 19% |
| Scientists | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 23% |
| Other | 4 | 15% |
| Student > Ph. D. Student | 3 | 12% |
| Student > Bachelor | 2 | 8% |
| Librarian | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 7 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 27% |
| Veterinary Science and Veterinary Medicine | 6 | 23% |
| Nursing and Health Professions | 2 | 8% |
| Environmental Science | 1 | 4% |
| Social Sciences | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 8 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2023.
All research outputs
#2,290,652
of 25,374,647 outputs
Outputs from Ophthalmology
#659
of 6,762 outputs
Outputs of similar age
#28,292
of 277,742 outputs
Outputs of similar age from Ophthalmology
#11
of 106 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,762 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.7. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,742 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 106 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.