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Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.

Overview of attention for article published in Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire), January 1994
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (85th percentile)
  • Good Attention Score compared to outputs of the same age and source (67th percentile)

Mentioned by

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8 patents

Citations

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463 Dimensions

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90 Mendeley
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Title
Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL.
Published in
Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire), January 1994
DOI 10.1161/01.atv.14.1.32
Pubmed ID
Authors

S Ylä-Herttuala, W Palinski, S W Butler, S Picard, D Steinberg, J L Witztum

Abstract

Atherosclerotic lesions contain relatively large quantities of IgG. We have previously shown that both human and rabbit sera contain autoantibodies against epitopes of oxidized (Ox) low-density lipoprotein (LDL) and that LDL isolated from atherosclerotic lesions contains small amounts of tightly bound IgG. However, it is not known whether IgG isolated from atherosclerotic lesions recognizes epitopes present in native LDL or Ox-LDL. IgG was isolated from Watanabe heritable hyperlipidemic (WHHL) rabbit atherosclerotic lesions by sequential salt extractions, purified by fast protein liquid chromatography on protein G, and used in a solid-phase radioimmunoassay. IgG and immune complexes were also isolated from the saline extracts of human lesions by adsorption onto latex beads coated with anti-human IgG antibodies or protein A. IgG isolated from rabbit lesions showed significant titers against malondialdehyde (MDA)-modified LDL and LDL oxidized by copper ions for 4 and 18 hours but not against native LDL. On Western blots, lesion IgG stained MDA-LDL and fragments of Ox-LDL. Western blots of immune complexes isolated from human lesions revealed the presence in the isolated complexes of both apoprotein B and apoprotein B fragments, which reacted with antibodies to MDA-lysine. Furthermore, rabbit lesion IgG immunostained epitopes of Ox-LDL present in human atherosclerotic lesions. Immunostains obtained with rabbit lesion IgG were similar to those obtained with a monoclonal antibody specific for MDA-lysine. The results show that human and rabbit atherosclerotic lesions contain IgG that recognizes epitopes characteristic of Ox-LDL. These data suggest that immunologic processes may be an important component of the atherogenic process.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
Bosnia and Herzegovina 1 1%
Canada 1 1%
Unknown 87 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 21 23%
Researcher 14 16%
Student > Master 13 14%
Student > Bachelor 8 9%
Student > Doctoral Student 5 6%
Other 14 16%
Unknown 15 17%
Readers by discipline Count As %
Medicine and Dentistry 27 30%
Agricultural and Biological Sciences 20 22%
Biochemistry, Genetics and Molecular Biology 11 12%
Immunology and Microbiology 5 6%
Neuroscience 3 3%
Other 6 7%
Unknown 18 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2014.
All research outputs
#5,446,210
of 25,371,288 outputs
Outputs from Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire)
#1,385
of 6,068 outputs
Outputs of similar age
#5,659
of 71,581 outputs
Outputs of similar age from Arteriosclerosis, Thrombosis, and Vascular Biology (Highwire)
#6
of 28 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 6,068 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 71,581 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 28 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.