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A comparative dose–response study of cartilage‐derived morphogenetic protein (CDMP)‐1, ‐2 and ‐3 for tendon healing in rats

Overview of attention for article published in Journal of Orthopaedic Research, January 2006
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

patent
3 patents

Citations

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105 Dimensions

Readers on

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32 Mendeley
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Title
A comparative dose–response study of cartilage‐derived morphogenetic protein (CDMP)‐1, ‐2 and ‐3 for tendon healing in rats
Published in
Journal of Orthopaedic Research, January 2006
DOI 10.1016/s0736-0266(03)00010-x
Pubmed ID
Authors

Carina Forslund, David Rueger, Per Aspenberg

Abstract

Cartilage-derived morphogenetic proteins (CDMPs), belonging to the bone morphogenetic protein (BMP) family, are known to be cartilage and bone inducers as well as to induce tendon and ligament-like tissue. In this study we investigated the influence of CDMP-1, -2 or -3 at four different doses (0, 0.4, 2 and 10 microg) on tendon healing in a rat model, as well as differences in osteogenesis between the different CDMPs and doses.In 110 rats, a 3 mm segment of the Achilles tendon was removed via a 2 mm skin incision. CDMP-1, -2 or -3 was injected into the defect 6 h postoperative. The rats were killed 8 days after operation. The tendon regenerates were tested biomechanically. There was a significant dose-related increase in strength and stiffness with all three CDMPs, but no difference between the CDMPs was found. Another 50 rats were used to compare the highest dose of the CDMPs with controls and osteogenic protein 1 (OP-1), as regards cartilage or bone formation after 4 weeks. Cartilage occurred in all groups, including the controls. Some specimens in all groups contained bone, except the controls. No difference between the CDMPs could be demonstrated. The CDMP-1, CDMP-3 and OP-1 groups contained significantly more calcium than controls. Only the CDMP-2 group and the controls contained significantly less calcium than the OP-1 group.In conclusion, the three CDMPs appeared similar as regards improvement of tendon repair and osteogenicity in this setting.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 3%
Unknown 31 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 28%
Researcher 6 19%
Student > Master 4 13%
Other 3 9%
Student > Doctoral Student 2 6%
Other 4 13%
Unknown 4 13%
Readers by discipline Count As %
Medicine and Dentistry 13 41%
Agricultural and Biological Sciences 6 19%
Engineering 3 9%
Chemistry 2 6%
Veterinary Science and Veterinary Medicine 1 3%
Other 3 9%
Unknown 4 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 April 2016.
All research outputs
#5,446,210
of 25,371,288 outputs
Outputs from Journal of Orthopaedic Research
#528
of 3,625 outputs
Outputs of similar age
#21,845
of 174,002 outputs
Outputs of similar age from Journal of Orthopaedic Research
#41
of 334 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,625 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 174,002 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 334 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.