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Mendeley readers
Attention Score in Context
| Title |
Pyrrolo-pyrimidones: A novel class of MK2 inhibitors with potent cellular activity
|
|---|---|
| Published in |
Bioorganic & Medicinal Chemistry Letters, October 2008
|
| DOI | 10.1016/j.bmcl.2008.10.039 |
| Pubmed ID | |
| Authors |
Achim Schlapbach, Roland Feifel, Stuart Hawtin, Richard Heng, Guido Koch, Henrik Moebitz, Laszlo Revesz, Clemens Scheufler, Juraj Velcicky, Rudolf Waelchli, Christine Huppertz |
| Abstract |
Pyrrolo-pyrimidones of the general structure 1 were synthesized and evaluated for their potential as MK2 inhibitors. Potent derivatives were discovered which inhibit MK2 in the nanomolar range and show potent inhibition of cytokine release from LPS-stimulated monocytes. These derivatives were shown to inhibit phosphorylation of hsp27, a downstream target of MK2 and are modestly selective in a panel of 28 kinases. |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| Unknown | 26 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 12 | 44% |
| Lecturer > Senior Lecturer | 3 | 11% |
| Student > Ph. D. Student | 2 | 7% |
| Student > Bachelor | 1 | 4% |
| Student > Master | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 5 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 11 | 41% |
| Agricultural and Biological Sciences | 3 | 11% |
| Medicine and Dentistry | 2 | 7% |
| Immunology and Microbiology | 1 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 2 | 7% |
| Unknown | 7 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2021.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from Bioorganic & Medicinal Chemistry Letters
#5,896
of 13,779 outputs
Outputs of similar age
#37,280
of 102,963 outputs
Outputs of similar age from Bioorganic & Medicinal Chemistry Letters
#86
of 168 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,779 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 13th percentile – i.e., 13% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 102,963 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 168 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.