| Title |
Regulation of cholesterol homeostasis
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, October 2011
|
| DOI | 10.1007/s00018-011-0857-5 |
| Pubmed ID | |
| Authors |
Leigh Goedeke, Carlos Fernández-Hernando |
| Abstract |
Cholesterol homeostasis is among the most intensely regulated processes in biology. Since its isolation from gallstones at the time of the French Revolution, cholesterol has been extensively studied. Insufficient or excessive cellular cholesterol results in pathological processes including atherosclerosis and metabolic syndrome. Mammalian cells obtain cholesterol from the circulation in the form of plasma lipoproteins or intracellularly, through the synthesis of cholesterol from acetyl coenzyme A (acetyl-CoA). This process is tightly regulated at multiple levels. In this review, we provide an overview of the multiple mechanisms by which cellular cholesterol metabolism is regulated. We also discuss the recent advances in the post-transcriptional regulation of cholesterol homeostasis, including the role of small non-coding RNAs (microRNAs). These novel findings may open new avenues for the treatment of dyslipidemias and cardiovascular diseases. |
Mendeley readers
The data shown below were compiled from readership statistics for 219 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Italy | 2 | <1% |
| Austria | 1 | <1% |
| Canada | 1 | <1% |
| Australia | 1 | <1% |
| Unknown | 209 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 44 | 20% |
| Student > Bachelor | 38 | 17% |
| Student > Master | 26 | 12% |
| Researcher | 23 | 11% |
| Student > Doctoral Student | 12 | 5% |
| Other | 29 | 13% |
| Unknown | 47 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 56 | 26% |
| Biochemistry, Genetics and Molecular Biology | 43 | 20% |
| Medicine and Dentistry | 31 | 14% |
| Nursing and Health Professions | 11 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 9 | 4% |
| Other | 17 | 8% |
| Unknown | 52 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 April 2018.
All research outputs
#2,050,760
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#233
of 4,151 outputs
Outputs of similar age
#10,365
of 141,498 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#2
of 40 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 141,498 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.