| Title |
Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations
|
|---|---|
| Published in |
Genes & Nutrition, October 2011
|
| DOI | 10.1007/s12263-011-0255-5 |
| Pubmed ID | |
| Authors |
Sebastian Schaffer, Barry Halliwell |
| Abstract |
Although several epidemiological and intervention studies suggest that polyphenols (PPs) and PP-rich foods may improve memory and cognition in animals and humans, PPs' mode of action is only poorly understood. To help distinguish between the different modes of action that have been proposed for PPs, it is obviously important to know how much PPs can accumulate in the brain, if any at all. However, reliable data on PP uptake into the brain of animals are limited as many studies failed to report important control procedures during data acquisition. In this paper, we summarize published data on the penetration of PPs into animal brain and review some hypotheses to explain the biological basis of potentially health-beneficial effects of PPs to the brain. Finally, we highlight promising new approaches, especially those of a hormetic dose-response and gut microbiota-brain interaction, which may allow a better understanding of PPs' mode of action in animals and humans. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 4 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 198 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 1% |
| United Kingdom | 2 | 1% |
| Switzerland | 1 | <1% |
| Greece | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 191 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 43 | 22% |
| Student > Master | 31 | 16% |
| Researcher | 25 | 13% |
| Student > Bachelor | 17 | 9% |
| Professor | 16 | 8% |
| Other | 37 | 19% |
| Unknown | 29 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 59 | 30% |
| Biochemistry, Genetics and Molecular Biology | 23 | 12% |
| Medicine and Dentistry | 15 | 8% |
| Psychology | 10 | 5% |
| Neuroscience | 10 | 5% |
| Other | 37 | 19% |
| Unknown | 44 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#13,880,400
of 24,764,450 outputs
Outputs from Genes & Nutrition
#174
of 405 outputs
Outputs of similar age
#87,485
of 143,933 outputs
Outputs of similar age from Genes & Nutrition
#2
of 4 outputs
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