| Title |
The role of regulatory T cells and microglia in glioblastoma-associated immunosuppression
|
|---|---|
| Published in |
Journal of Neuro-Oncology, June 2015
|
| DOI | 10.1007/s11060-015-1849-3 |
| Pubmed ID | |
| Authors |
Alfred P. See, Jonathon J. Parker, Allen Waziri |
| Abstract |
Cell-mediated suppression of anti-tumor immunity is multifactorial in patients with cancer, and recent studies have focused on several distinct cellular agents that are associated with this phenomenon. This review will focus on the potential role of regulatory T cells (Tregs) and microglia in the suppression of cellular immunity observed in patients with glioblastoma. We discuss the ontogeny, basic biology, evidence for activity, and potential clinical options for targeting Tregs and microglia as part of immunotherapy in affected patients. |
Mendeley readers
The data shown below were compiled from readership statistics for 86 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Mexico | 1 | 1% |
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Brazil | 1 | 1% |
| Unknown | 82 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 19% |
| Student > Master | 16 | 19% |
| Student > Bachelor | 10 | 12% |
| Researcher | 9 | 10% |
| Student > Doctoral Student | 7 | 8% |
| Other | 15 | 17% |
| Unknown | 13 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 23% |
| Biochemistry, Genetics and Molecular Biology | 14 | 16% |
| Neuroscience | 12 | 14% |
| Agricultural and Biological Sciences | 10 | 12% |
| Immunology and Microbiology | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 16 | 19% |