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Novel Missense Variants of Prion Protein in Creutzfeldt-Jakob Disease or Gerstmann-Sträussler Syndrome

Overview of attention for article published in Biochemical & Biophysical Research Communications, March 1993
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

policy
1 policy source
patent
2 patents

Citations

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160 Dimensions

Readers on

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48 Mendeley
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Title
Novel Missense Variants of Prion Protein in Creutzfeldt-Jakob Disease or Gerstmann-Sträussler Syndrome
Published in
Biochemical & Biophysical Research Communications, March 1993
DOI 10.1006/bbrc.1993.1275
Pubmed ID
Authors

T. Kitamoto, M. Ohta, K. Dohura, S. Hitoshi, Y. Terao, J. Tateishi

Abstract

We found 3 novel missense variants in the open reading frame of the prion protein (PrP) gene. The codon 105 point mutation (proline to leucine) was found on a codon 129 (Valine) PrP allele in 4 patients from 3 different Japanese families with Gerstmann-Sträussler syndrome. The codon 180 variant PrP (valine to isoleucine) was found in Creutzfeldt-Jakob disease (CJD) patients with a similar clinical course to that of codon 178 mutation. The codon 232 variant PrP (methionine to arginine) was documented in the CJD patients with typical clinical and pathological findings. These variant PrP molecules were not detected in 200 normal Japanese PrP alleles. PrP has a large repertoire of variant forms, and each primary structure of PrP corresponds to the distinct phenotype of prion diseases.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 23%
Student > Ph. D. Student 9 19%
Professor 5 10%
Other 5 10%
Student > Bachelor 4 8%
Other 8 17%
Unknown 6 13%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 14 29%
Medicine and Dentistry 8 17%
Neuroscience 7 15%
Agricultural and Biological Sciences 6 13%
Immunology and Microbiology 2 4%
Other 5 10%
Unknown 6 13%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2010.
All research outputs
#3,799,086
of 25,377,790 outputs
Outputs from Biochemical & Biophysical Research Communications
#1,281
of 26,637 outputs
Outputs of similar age
#1,158
of 19,334 outputs
Outputs of similar age from Biochemical & Biophysical Research Communications
#4
of 112 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 26,637 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 19,334 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 112 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.