| Title |
Incidence and outcomes of acute kidney injury after cardiac surgery using either criteria of the RIFLE classification
|
|---|---|
| Published in |
BMC Nephrology, May 2015
|
| DOI | 10.1186/s12882-015-0066-9 |
| Pubmed ID | |
| Authors |
Marc-Gilbert Lagny, François Jouret, Jean-Noël Koch, Francine Blaffart, Anne-Françoise Donneau, Adelin Albert, Laurence Roediger, Jean-Marie Krzesinski, Jean-Olivier Defraigne |
| Abstract |
Adult cardiac surgery is significantly associated with the development of acute kidney injury (AKI). Still, the incidence and outcomes of AKI vary according to its definition. Our retrospective monocentric study comparatively investigates the yield of RIFLE definition, which is based on the elevation of serum creatinine levels (SCr) or the reduction of urine output (UO), taking into account only one or both criteria. Pre- and per-operative risk factors for post-operative AKI were evaluated. All adult patients undergoing cardiac surgery, with or without cardiopulmonary bypass, from April 2008 to March 2009 were included. Clinical, biological and surgical features were recorded. Baseline serum creatinine was determined as its value on day 7 before surgery. Post-operative AKI was diagnosed and scored based upon the highest serum creatinine and/or the lowest urine output. 443 patients (Male/Female ratio, 2.3; median age, 69y) were included, with 221 (49.9 %) developing postoperative AKI. Elevated serum creatinine (AKISCr) and oliguria (AKIUO) was observed in 9.7 % and 40.2 %, respectively. AKI patients had a significantly higher BMI and baseline SCr. In comparison to AKIUO, AKISCr mostly occurred in patients with co-morbidities, and was associated with an increased mortality at 1-year post surgery. The use of standard RIFLE definition of AKI in a cohort of 443 patients undergoing cardiac surgery resulted in an incidence reaching 50 %. Still, significant discrepancies were found between AKISCr and AKIUO regarding the incidence and outcomes. In line with previous reports, our data questions the utility of urine output as a criterion for AKI diagnosis and management after cardiac surgery. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 125 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Unknown | 124 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 18 | 14% |
| Student > Master | 18 | 14% |
| Student > Postgraduate | 13 | 10% |
| Student > Bachelor | 12 | 10% |
| Other | 10 | 8% |
| Other | 26 | 21% |
| Unknown | 28 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 61 | 49% |
| Nursing and Health Professions | 9 | 7% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Agricultural and Biological Sciences | 3 | 2% |
| Other | 11 | 9% |
| Unknown | 31 | 25% |
Attention Score in Context
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#20,282,766
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Outputs from BMC Nephrology
#2,179
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Outputs of similar age from BMC Nephrology
#39
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