Title |
Severe Asthma in School-Age Children: Evaluation and Phenotypic Advances
|
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Published in |
Current Allergy and Asthma Reports, July 2015
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DOI | 10.1007/s11882-015-0521-5 |
Pubmed ID | |
Authors |
Andrea Coverstone, Leonard B. Bacharier, Anne M. Fitzpatrick |
Abstract |
Although the majority of children with asthma have a favorable clinical response to treatment with low to moderate doses of inhaled corticosteroids (ICS), a small subset of children have "severe" asthma characterized by ongoing symptoms and airway inflammation despite treatment with high doses of ICS and even oral corticosteroids. Although there is symptom heterogeneity in the affected children, children with severe asthma share the risk for adverse outcomes, including recurrent and potentially life-threatening exacerbations, which contribute to substantial economic burden. This article reviews current knowledge of severe asthma in school-age children (age 6-17 years) with a focus on recent literature published after January 2012. Clinical management approaches for children with severe asthma are discussed as well as current phenotyping efforts and emerging phenotypic-directed therapies that may be of benefit for subpopulations of children with severe asthma in the future. |
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Mexico | 1 | 20% |
Spain | 1 | 20% |
United Kingdom | 1 | 20% |
Unknown | 2 | 40% |
Demographic breakdown
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Members of the public | 4 | 80% |
Practitioners (doctors, other healthcare professionals) | 1 | 20% |
Mendeley readers
Geographical breakdown
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Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 3 | 9% |
Researcher | 3 | 9% |
Other | 3 | 9% |
Student > Bachelor | 3 | 9% |
Librarian | 2 | 6% |
Other | 7 | 21% |
Unknown | 13 | 38% |
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Unspecified | 1 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
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Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 2 | 6% |
Unknown | 14 | 41% |