| Title |
Systematic review of models assessing the economic value of routine varicella and herpes zoster vaccination in high-income countries
|
|---|---|
| Published in |
BMC Public Health, June 2015
|
| DOI | 10.1186/s12889-015-1861-8 |
| Pubmed ID | |
| Authors |
Oliver Damm, Bernhard Ultsch, Johannes Horn, Rafael T. Mikolajczyk, Wolfgang Greiner, Ole Wichmann |
| Abstract |
A systematic review was conducted to assess the cost-effectiveness of routine varicella and herpes zoster (HZ) vaccination in high-income countries estimated by modelling studies. A PubMed search was performed to identify relevant studies published before October 2013. Studies were included in the review if they (i) evaluated the cost-effectiveness of routine childhood or adolescent varicella vaccination and/or HZ vaccination targeting the elderly, and if they (ii) reported results for high-income countries. A total of 38 model-based studies were identified that fulfilled the inclusion criteria. Routine childhood or adolescent varicella vaccination was cost-effective or cost-saving from a payer perspective and always cost-saving from a societal perspective when ignoring its potential impact on HZ incidence due to reduced or absent exogenous boosting. The inclusion of the potential impact of childhood varicella vaccination on HZ led to net quality-adjusted life-year (QALY) losses or incremental cost-effectiveness ratios exceeding commonly accepted thresholds. Additional HZ vaccination could partially mitigate this effect. Studies focusing only on the evaluation of HZ vaccination reported a wide range of results depending on the selected target age-group and the vaccine price, but most found HZ vaccination to be a cost-effective or marginally cost-effective intervention. Cost-effectiveness of HZ vaccination was strongly dependent on the age at vaccination, the price of the vaccine, the assumed duration of protection and the applied cost per QALY threshold. While HZ vaccination is mostly considered cost-effective, cost-effectiveness of varicella vaccination primarily depends on the in- or exclusion of exogenous boosting in the model. As a consequence, clarification on the role of exogenous boosting is crucial for decision-making regarding varicella vaccination. |
X Demographics
The data shown below were collected from the profiles of 14 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 9 | 64% |
| Argentina | 1 | 7% |
| Unknown | 4 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 79% |
| Practitioners (doctors, other healthcare professionals) | 2 | 14% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| Portugal | 1 | <1% |
| Italy | 1 | <1% |
| Germany | 1 | <1% |
| Unknown | 98 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 25% |
| Student > Master | 22 | 21% |
| Student > Ph. D. Student | 11 | 11% |
| Other | 8 | 8% |
| Student > Doctoral Student | 6 | 6% |
| Other | 11 | 11% |
| Unknown | 19 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 28% |
| Social Sciences | 9 | 9% |
| Economics, Econometrics and Finance | 8 | 8% |
| Nursing and Health Professions | 6 | 6% |
| Agricultural and Biological Sciences | 6 | 6% |
| Other | 20 | 19% |
| Unknown | 25 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 October 2019.
All research outputs
#2,419,234
of 25,081,419 outputs
Outputs from BMC Public Health
#2,815
of 16,723 outputs
Outputs of similar age
#30,016
of 272,416 outputs
Outputs of similar age from BMC Public Health
#42
of 230 outputs
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