Title |
PPARδ is a very low-density lipoprotein sensor in macrophages
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Published in |
Proceedings of the National Academy of Sciences of the United States of America, January 2003
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DOI | 10.1073/pnas.0337331100 |
Pubmed ID | |
Authors |
Ajay Chawla, Chih-Hao Lee, Yaacov Barak, Weimin He, John Rosenfeld, Debbie Liao, Jungyeob Han, Heonjoong Kang, Ronald M. Evans |
Abstract |
Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor delta. The signaling components of native VLDL are its triglycerides, whose activity is enhanced by lipoprotein lipase. Generation of peroxisome proliferator-activated receptor delta null macrophages verifies the absolute requirement of this transcription factor in mediating the VLDL response. Thus, our data reveal a pathway through which dietary triglycerides and VLDL can directly regulate gene expression in atherosclerotic lesions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 3% |
Japan | 1 | 1% |
United Kingdom | 1 | 1% |
Canada | 1 | 1% |
Unknown | 71 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 14 | 18% |
Researcher | 13 | 17% |
Professor | 8 | 11% |
Student > Bachelor | 7 | 9% |
Professor > Associate Professor | 7 | 9% |
Other | 18 | 24% |
Unknown | 9 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 31 | 41% |
Medicine and Dentistry | 14 | 18% |
Biochemistry, Genetics and Molecular Biology | 9 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 5% |
Nursing and Health Professions | 1 | 1% |
Other | 3 | 4% |
Unknown | 14 | 18% |