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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis
|
|---|---|
| Published in |
Nature Communications, July 2015
|
| DOI | 10.1038/ncomms8286 |
| Pubmed ID | |
| Authors |
Sabu Abraham, Margherita Scarcia, Richard D. Bagshaw, Kathryn McMahon, Gary Grant, Tracey Harvey, Maggie Yeo, Filomena O.G. Esteves, Helene H. Thygesen, Pamela F. Jones, Valerie Speirs, Andrew M. Hanby, Peter J. Selby, Mihaela Lorger, T. Neil Dear, Tony Pawson, Christopher J. Marshall, Georgia Mavria |
| Abstract |
During angiogenesis, Rho-GTPases influence endothelial cell migration and cell-cell adhesion; however it is not known whether they control formation of vessel lumens, which are essential for blood flow. Here, using an organotypic system that recapitulates distinct stages of VEGF-dependent angiogenesis, we show that lumen formation requires early cytoskeletal remodelling and lateral cell-cell contacts, mediated through the RAC1 guanine nucleotide exchange factor (GEF) DOCK4 (dedicator of cytokinesis 4). DOCK4 signalling is necessary for lateral filopodial protrusions and tubule remodelling prior to lumen formation, whereas proximal, tip filopodia persist in the absence of DOCK4. VEGF-dependent Rac activation via DOCK4 is necessary for CDC42 activation to signal filopodia formation and depends on the activation of RHOG through the RHOG GEF, SGEF. VEGF promotes interaction of DOCK4 with the CDC42 GEF DOCK9. These studies identify a novel Rho-family GTPase activation cascade for the formation of endothelial cell filopodial protrusions necessary for tubule remodelling, thereby influencing subsequent stages of lumen morphogenesis. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 60% |
| Australia | 1 | 20% |
| Canada | 1 | 20% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 60% |
| Scientists | 2 | 40% |
Mendeley readers
The data shown below were compiled from readership statistics for 140 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | <1% |
| Unknown | 139 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 40 | 29% |
| Researcher | 27 | 19% |
| Student > Bachelor | 14 | 10% |
| Student > Master | 11 | 8% |
| Professor | 8 | 6% |
| Other | 21 | 15% |
| Unknown | 19 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 56 | 40% |
| Agricultural and Biological Sciences | 37 | 26% |
| Medicine and Dentistry | 8 | 6% |
| Engineering | 4 | 3% |
| Immunology and Microbiology | 2 | 1% |
| Other | 6 | 4% |
| Unknown | 27 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 43. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 August 2015.
All research outputs
#811,330
of 22,710,079 outputs
Outputs from Nature Communications
#13,508
of 46,749 outputs
Outputs of similar age
#10,607
of 263,247 outputs
Outputs of similar age from Nature Communications
#156
of 790 outputs
Altmetric has tracked 22,710,079 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 46,749 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.5. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,247 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 790 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 80% of its contemporaries.