| Title |
Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease
|
|---|---|
| Published in |
Digestive Diseases and Sciences, July 2015
|
| DOI | 10.1007/s10620-015-3769-7 |
| Pubmed ID | |
| Authors |
Martina Klemenak, Jernej Dolinšek, Tomaž Langerholc, Diana Di Gioia, Dušanka Mičetić-Turk |
| Abstract |
Increasing evidence suggests that not only genetics, but also environmental factors like gut microbiota dysbiosis play an important role in the pathogenesis of celiac disease (CD). The aim of our study was to investigate the effect of two probiotic strains Bifidobacterium breve BR03 and B. breve B632 on serum production of anti-inflammatory cytokine interleukin 10 (IL-10) and pro-inflammatory cytokine tumor necrosis factor alpha (TNF-α) in children with CD. The study was a double-blinded, placebo-controlled trial that included 49 children with CD on gluten-free diet (GFD) randomized into two groups and 18 healthy children in the control group. The first group (24 children with CD) daily received B. breve BR03 and B632 (2 × 10(9) colony-forming units) and the second group (25 children with CD) received placebo for 3 months. TNF-α levels were significantly decreased in the first group after receiving B. breve for 3 months. On follow-up, 3 months after receiving probiotics, TNF-α levels increased again. Children with CD who were on GFD for less than 1 year showed similar baseline TNF-α levels as children who were on GFD for more than 1 year. IL-10 levels were in all groups of patients below detection level. Probiotic intervention with B. breve strains has shown a positive effect on decreasing the production of pro-inflammatory cytokine TNF-α in children with CD on GFD. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 25% |
| Canada | 1 | 13% |
| Unknown | 5 | 63% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 194 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Austria | 1 | <1% |
| Unknown | 193 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 34 | 18% |
| Researcher | 27 | 14% |
| Student > Master | 27 | 14% |
| Student > Ph. D. Student | 16 | 8% |
| Other | 12 | 6% |
| Other | 33 | 17% |
| Unknown | 45 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 47 | 24% |
| Agricultural and Biological Sciences | 30 | 15% |
| Immunology and Microbiology | 16 | 8% |
| Biochemistry, Genetics and Molecular Biology | 15 | 8% |
| Nursing and Health Professions | 13 | 7% |
| Other | 18 | 9% |
| Unknown | 55 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 September 2021.
All research outputs
#3,391,598
of 25,654,806 outputs
Outputs from Digestive Diseases and Sciences
#420
of 4,702 outputs
Outputs of similar age
#41,071
of 278,075 outputs
Outputs of similar age from Digestive Diseases and Sciences
#2
of 62 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,702 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,075 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.