| Title |
Alcohol consumption and liver cancer risk: a meta-analysis
|
|---|---|
| Published in |
Cancer Causes & Control, July 2015
|
| DOI | 10.1007/s10552-015-0615-3 |
| Pubmed ID | |
| Authors |
Shu-Chun Chuang, Yuan-Chin Amy Lee, Guo-Jie Wu, Kurt Straif, Mia Hashibe |
| Abstract |
Alcohol is a confirmed risk factor of liver cancer. Yet, its dose-response function and synergistic effects with other risk factors remain unclear. We performed a meta-analysis on publications up to May 2014. A total of 112 publications were identified. The meta-relative risk (mRR) and the dose-response trend were calculated. Tests for heterogeneity, publication bias, and sensitivity analyses were performed. The synergy index (SI) was recorded or calculated, whenever possible. Compared to individuals who never drank or drank at very low frequencies, the mRR for ever drinkers was 1.29 (95 % confidence interval, CI 1.16-1.42) and 1.46 (95 % CI 1.27-1.65) for case-control studies, and 1.07 (95 % CI 0.87-1.27) for cohort studies. Being a current drinker was associated with an increased liver cancer risk in case-control studies (mRR = 1.55, 95 % CI 0.38-2.73), but not in cohort studies (mRR = 0.86, 95 % CI 0.74-0.97). The dose-response relation between alcohol and liver cancer was apparent with RR = 1.08 (95 % CI 1.04-1.11) for 12 g/day (~1 drink), 1.54 (95 % CI 1.36-1.74) for 50 g/day, 2.14 (95 % CI 1.74-2.62) for 75 g/day, 3.21 (95 % CI 2.34-4.40) for 100 g/day, and 5.20 (95 % CI 3.25-8.29) for 125 g/day of alcohol consumption. There were synergistic effects of alcohol consumption with hepatitis (S = 2.14, 95 % CI 1.31-2.98) and with diabetes (S = 3.57, 95 % CI 2.29-4.84) on the risk of liver cancer, although this may be subject to publication bias. Overall, one alcoholic drink per day (~12 g/day) may be associated with a 1.1 times higher liver cancer risk. Further studies on the synergistic effects of alcohol consumption and other major risk factors are warranted. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 17% |
| United Kingdom | 1 | 17% |
| United States | 1 | 17% |
| Unknown | 3 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 3 | 50% |
| Members of the public | 2 | 33% |
| Science communicators (journalists, bloggers, editors) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 79 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 14 | 18% |
| Student > Master | 13 | 16% |
| Researcher | 12 | 15% |
| Student > Ph. D. Student | 5 | 6% |
| Other | 4 | 5% |
| Other | 9 | 11% |
| Unknown | 22 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 20 | 25% |
| Nursing and Health Professions | 6 | 8% |
| Psychology | 5 | 6% |
| Biochemistry, Genetics and Molecular Biology | 4 | 5% |
| Unspecified | 4 | 5% |
| Other | 13 | 16% |
| Unknown | 27 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 58. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2024.
All research outputs
#736,227
of 25,632,496 outputs
Outputs from Cancer Causes & Control
#60
of 2,272 outputs
Outputs of similar age
#8,346
of 278,033 outputs
Outputs of similar age from Cancer Causes & Control
#2
of 28 outputs
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