| Title |
Effect of Kidney Function on Drug Kinetics and Dosing in Neonates, Infants, and Children
|
|---|---|
| Published in |
Clinical Pharmacokinetics, July 2015
|
| DOI | 10.1007/s40262-015-0298-7 |
| Pubmed ID | |
| Authors |
Frederique Rodieux, Melanie Wilbaux, Johannes N. van den Anker, Marc Pfister |
| Abstract |
Neonates, infants, and children differ from adults in many aspects, not just in age, weight, and body composition. Growth, maturation and environmental factors affect drug kinetics, response and dosing in pediatric patients. Almost 80 % of drugs have not been studied in children, and dosing of these drugs is derived from adult doses by adjusting for body weight/size. As developmental and maturational changes are complex processes, such simplified methods may result in subtherapeutic effects or adverse events. Kidney function is impaired during the first 2 years of life as a result of normal growth and development. Reduced kidney function during childhood has an impact not only on renal clearance but also on absorption, distribution, metabolism and nonrenal clearance of drugs. 'Omics'-based technologies, such as proteomics and metabolomics, can be leveraged to uncover novel markers for kidney function during normal development, acute kidney injury, and chronic diseases. Pharmacometric modeling and simulation can be applied to simplify the design of pediatric investigations, characterize the effects of kidney function on drug exposure and response, and fine-tune dosing in pediatric patients, especially in those with impaired kidney function. One case study of amikacin dosing in neonates with reduced kidney function is presented. Collaborative efforts between clinicians and scientists in academia, industry, and regulatory agencies are required to evaluate new renal biomarkers, collect and share prospective pharmacokinetic, genetic and clinical data, build integrated pharmacometric models for key drugs, optimize and standardize dosing strategies, develop bedside decision tools, and enhance labels of drugs utilized in neonates, infants, and children. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 44% |
| Unknown | 5 | 56% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 89% |
| Practitioners (doctors, other healthcare professionals) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 164 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 1% |
| United States | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 160 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 12% |
| Student > Master | 18 | 11% |
| Researcher | 17 | 10% |
| Other | 15 | 9% |
| Student > Bachelor | 15 | 9% |
| Other | 35 | 21% |
| Unknown | 45 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 46 | 28% |
| Pharmacology, Toxicology and Pharmaceutical Science | 35 | 21% |
| Agricultural and Biological Sciences | 7 | 4% |
| Biochemistry, Genetics and Molecular Biology | 6 | 4% |
| Nursing and Health Professions | 3 | 2% |
| Other | 16 | 10% |
| Unknown | 51 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2015.
All research outputs
#6,316,729
of 25,101,232 outputs
Outputs from Clinical Pharmacokinetics
#492
of 1,603 outputs
Outputs of similar age
#66,656
of 268,576 outputs
Outputs of similar age from Clinical Pharmacokinetics
#6
of 19 outputs
Altmetric has tracked 25,101,232 research outputs across all sources so far. This one has received more attention than most of these and is in the 74th percentile.
So far Altmetric has tracked 1,603 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,576 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 75% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.