| Title |
Low vitamin D status is associated with more depressive symptoms in Dutch older adults
|
|---|---|
| Published in |
European Journal of Nutrition, July 2015
|
| DOI | 10.1007/s00394-015-0970-6 |
| Pubmed ID | |
| Authors |
E. M. Brouwer-Brolsma, R. A. M. Dhonukshe-Rutten, J. P. van Wijngaarden, N. L. van der Zwaluw, E. Sohl, P. H. In’t Veld, S. C. van Dijk, K. M. A. Swart, A. W. Enneman, A. C. Ham, N. M. van Schoor, N. van der Velde, A. G. Uitterlinden, P. Lips, E. J. M. Feskens, L. C. P. G. M. de Groot |
| Abstract |
The existence of vitamin D receptors in the brain points to a possible role of vitamin D in brain function. We examined the association of vitamin D status and vitamin D-related genetic make-up with depressive symptoms amongst 2839 Dutch older adults aged ≥65 years. 25-Hydroxyvitamin D (25(OH)D) was measured, and five 'vitamin D-related genes' were selected. Depressive symptoms were measured with the 15-point Geriatric Depression Scale. Results were expressed as the relative risk of the score of depressive symptoms by quartiles of 25(OH)D concentration or number of affected alleles, using the lowest quartile or minor allele group as reference. A clear cross-sectional and prospective association between serum 25(OH)D and depressive symptom score was observed. Fully adjusted models indicated a 22 % (RR 0.78, 95 % CI 0.68-0.89), 21 % (RR 0.79, 95 % CI 0.68-0.90), and 18 % (RR 0.82, 95 % CI 0.71-0.95) lower score of depressive symptoms in people in the second, third, and fourth 25(OH)D quartiles, when compared to people in the first quartile (P for trend <0.0001). After 2 years of daily 15 µg vitamin D supplementation, similar associations were observed. 25(OH)D concentrations did not significantly interact with the selected genes. Low serum 25(OH)D was associated with higher depressive symptom scores. No interactions between 25(OH)D concentrations and vitamin D genetic make-up were observed. In view of the probability of reverse causation, we propose that the association should be further examined in prospective studies as well as in randomized controlled trials. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 115 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 115 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 19 | 17% |
| Student > Bachelor | 16 | 14% |
| Other | 13 | 11% |
| Researcher | 8 | 7% |
| Student > Ph. D. Student | 8 | 7% |
| Other | 19 | 17% |
| Unknown | 32 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 29 | 25% |
| Nursing and Health Professions | 15 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 6% |
| Agricultural and Biological Sciences | 6 | 5% |
| Psychology | 5 | 4% |
| Other | 15 | 13% |
| Unknown | 38 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 July 2015.
All research outputs
#17,489,487
of 25,654,806 outputs
Outputs from European Journal of Nutrition
#1,999
of 2,708 outputs
Outputs of similar age
#165,666
of 277,186 outputs
Outputs of similar age from European Journal of Nutrition
#32
of 58 outputs
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