| Title |
FDG-PET/CT findings in systemic mastocytosis: a French multicentre study
|
|---|---|
| Published in |
European Journal of Nuclear Medicine and Molecular Imaging, July 2015
|
| DOI | 10.1007/s00259-015-3117-3 |
| Pubmed ID | |
| Authors |
S. Djelbani-Ahmed, M. O. Chandesris, A. Mekinian, D. Canioni, C. Brouzes, K. Hanssens, G. Pop, I. Durieu, S. Durupt, B. Grosbois, S. Besnard, O. Tournilhac, O. Beyne-Rauzy, P. Agapé, A. Delmer, D. Ranta, P. Y. Jeandel, S. Georgin-Lavialle, L. Frenzel, G. Damaj, V. Eder, O. Lortholary, O. Hermine, O. Fain, M. Soussan |
| Abstract |
Mastocytosis is a clonal haematological disease characterized by uncontrolled proliferation and the activation of mast cells. The value of FDG-PET/CT (FDG-PET) in mastocytosis has yet to be determined. We retrospectively identified patients with an established diagnosis of systemic mastocytosis (SM), according to the WHO criteria, who underwent PET using the French Reference Centre for Mastocytosis database. Semi-quantitative and visual analysis of FDG-PET was performed and compared to the clinico-biological data. Our cohort included 19 adult patients, median age 65 years [range 58-74], including three with smouldering SM (SSM), three with aggressive SM (ASM), 10 with an associated clonal haematological non-mast-cell lineage disease (SM-AHNMD), and three with mast cell sarcoma (MCS). FDG-PET was performed at the time of the SM diagnosis (15/19), to evaluate lymph node (LN) activity (3/19) or the efficacy of therapy (1/19). FDG uptake was observed in the bone marrow (BM) (9/19, 47 %), LN (6/19, 32 %), spleen (12/19, 63 %), or liver (1/19, 5 %). No significant FDG uptake was observed in the SSM and ASM patients. A pathological FDG uptake was observed in the BM of 6/10 patients with SM-AHNMD, appearing as diffuse and homogeneous, and in the LN of 5/10 patients. All 3 MCS patients showed intense and multifocal BM pathological uptake, mimicking metastasis. No correlation was found between the FDG-PET findings and serum tryptase levels, BM mast cell infiltration percentage, and CD30 and CD2 expression by mast cells. FDG uptake does not appear to be a sensitive marker of mast cell activation or proliferation because no significant FDG uptake was observed in most common forms of mastocytosis (notably purely aggressive SM). However, pathological FDG uptake was observed in the SM-AHNMD and in MCS cases, suggesting a role of FDG-PET in their early identification and as a tool of therapeutic assessment in this subgroup of patients. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 4% |
| Brazil | 1 | 4% |
| Unknown | 21 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Professor | 5 | 22% |
| Other | 4 | 17% |
| Researcher | 3 | 13% |
| Student > Master | 3 | 13% |
| Professor > Associate Professor | 2 | 9% |
| Other | 5 | 22% |
| Unknown | 1 | 4% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 14 | 61% |
| Chemistry | 2 | 9% |
| Chemical Engineering | 1 | 4% |
| Social Sciences | 1 | 4% |
| Business, Management and Accounting | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 2 | 9% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 August 2016.
All research outputs
#14,882,733
of 23,806,312 outputs
Outputs from European Journal of Nuclear Medicine and Molecular Imaging
#1,782
of 3,083 outputs
Outputs of similar age
#137,436
of 263,755 outputs
Outputs of similar age from European Journal of Nuclear Medicine and Molecular Imaging
#23
of 65 outputs
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