Title |
Initiation of biological agents in patients with ankylosing spondylitis: results of a Delphi study by the ASAS Group
|
---|---|
Published in |
Annals of the Rheumatic Diseases, August 2003
|
DOI | 10.1136/ard.62.9.812 |
Pubmed ID | |
Authors |
T Pham, D van der Heijde, A Calin, M A Khan, Sj van der Linden, N Bellamy, M Dougados |
Abstract |
There is ample evidence of important symptomatic efficacy of tumour necrosis factor alpha (TNFalpha) inhibition in ankylosing spondylitis (AS). Moreover, studies suggest that anti-TNF could be considered as the first disease controlling antirheumatic treatment (DC-ART) for AS. To determine precisely which patients with AS are most likely to benefit from anti-TNFalpha treatment because of the cost and possible long term side effects of such treatment. Assessment in Ankylosing Spondylitis (ASAS) members were asked to use a Delphi technique to name the characteristics of patients with AS for whom they would start DC-ART, in three different clinical presentations (isolated axial involvement, peripheral arthritis, enthesitis). Among the 62 invited ASAS members, more than 50% actively participated in the four phases of definition according to the Delphi technique. For each of the three clinical presentations, a combination of five to six domains was proposed, with an evaluation instrument and a cut off point defining a minimum level of activity for each domain. This study provides a profile for a patient with AS for considering initiation of biological agents that reflects the opinion of the ASAS members, using a Delphi exercise. Further studies are required to assess their relevance and their consistency with clinical practice. |
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Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 2 | 7% |
France | 1 | 3% |
Unknown | 26 | 90% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 5 | 17% |
Other | 3 | 10% |
Student > Doctoral Student | 3 | 10% |
Student > Postgraduate | 3 | 10% |
Professor > Associate Professor | 3 | 10% |
Other | 8 | 28% |
Unknown | 4 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 15 | 52% |
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Social Sciences | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Nursing and Health Professions | 1 | 3% |
Other | 1 | 3% |
Unknown | 6 | 21% |