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Alopecia areata: a review of disease pathogenesis

Overview of attention for article published in British Journal of Dermatology, September 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (93rd percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
4 news outlets
twitter
12 X users
wikipedia
7 Wikipedia pages

Citations

dimensions_citation
194 Dimensions

Readers on

mendeley
225 Mendeley
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Title
Alopecia areata: a review of disease pathogenesis
Published in
British Journal of Dermatology, September 2018
DOI 10.1111/bjd.16808
Pubmed ID
Authors

F. Rajabi, L.A. Drake, M.M. Senna, N. Rezaei

Abstract

Alopecia areata is a disorder that results in non-scarring hair loss. The psychological impact can be significant, leading to feelings of depression and social isolation. The disease remains incurable though it has been studied for years. Available treatment options at best, are beneficial for milder cases, and the rate of relapse is high. Understanding the exact mechanisms of hair loss in alopecia areata is therefore of utmost importance to help identify potential therapeutic targets. The main theory of alopecia areata pathogenesis is that it is an autoimmune phenomenon resulting from a disruption in hair follicle immune privilege. What causes this breakdown is an issue of debate. Some believe that stressed hair follicle environment triggers antigen presentation while others blame a dysregulation in the central immune system to entangle the follicles. Evidence for the latter theory is provided by animal studies as well investigation around the AIRE gene. Different immune cell lines including plasmacytoid dendritic cells, natural killer cells, and T-cells along with key molecules such as IFNγ, IL-15, MICA, and NKG2D have been identified to contribute to the autoimmune process. In this article, we seek to review the pathophysiologic mechanisms proposed in recent years in a narrative fashion. This article is protected by copyright. All rights reserved.

X Demographics

X Demographics

The data shown below were collected from the profiles of 12 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 225 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 225 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 31 14%
Student > Master 23 10%
Researcher 20 9%
Other 19 8%
Student > Doctoral Student 14 6%
Other 28 12%
Unknown 90 40%
Readers by discipline Count As %
Medicine and Dentistry 68 30%
Biochemistry, Genetics and Molecular Biology 13 6%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Chemistry 6 3%
Agricultural and Biological Sciences 5 2%
Other 27 12%
Unknown 99 44%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 42. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 August 2023.
All research outputs
#983,219
of 25,463,091 outputs
Outputs from British Journal of Dermatology
#256
of 9,683 outputs
Outputs of similar age
#20,850
of 346,795 outputs
Outputs of similar age from British Journal of Dermatology
#5
of 180 outputs
Altmetric has tracked 25,463,091 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,683 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.6. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,795 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 180 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.