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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Enhanced brain penetration of pretomanid by intranasal administration of an oil-in-water nanoemulsion
|
|---|---|
| Published in |
Nanomedicine, May 2018
|
| DOI | 10.2217/nnm-2017-0365 |
| Pubmed ID | |
| Authors |
Adeola Shobo, Annapurna Pamreddy, Hendrik G Kruger, Maya M Makatini, Tricia Naicker, Thavendran Govender, Sooraj Baijnath |
| Abstract |
To enhance the drug delivery to the brain with an oil-in-water nanoemulsion of pretomanid via intranasal (IN) administration. The study involved 70 male Sprague-Dawley rats (160-180 g) that received either 20 mg/kg body weight (b.w.) a nanoemulsion or a 20 mg/kg b.w. of pretomanid in solution via the IN route. The drug was quantified by liquid chromatography-tandem mass spectrometry to investigate whole tissue-drug concentrations, and mass spectrometric imaging to visualize drug localization in the brain. Nanoemulsion delivery concentrations of pretomanid in the brain reached peak concentrations (Cmax) of 12,062.3 ng/g that is significantly higher than the required therapeutic level. The mass spectrometric imaging analysis clearly showed a time dependent and uniform distribution in the brain. The results of this study show that IN delivery of oil-in-water nanoemulsion may be very promising for targeting anatomical tuberculosis reservoirs, such as the brain. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 43 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 9% |
| Other | 3 | 7% |
| Professor > Associate Professor | 3 | 7% |
| Student > Bachelor | 2 | 5% |
| Lecturer > Senior Lecturer | 2 | 5% |
| Other | 7 | 16% |
| Unknown | 22 | 51% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 14% |
| Medicine and Dentistry | 6 | 14% |
| Neuroscience | 2 | 5% |
| Chemistry | 2 | 5% |
| Economics, Econometrics and Finance | 1 | 2% |
| Other | 2 | 5% |
| Unknown | 24 | 56% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2018.
All research outputs
#17,292,294
of 25,382,440 outputs
Outputs from Nanomedicine
#885
of 1,455 outputs
Outputs of similar age
#221,987
of 343,952 outputs
Outputs of similar age from Nanomedicine
#8
of 19 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,455 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,952 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.