Title |
Development of a Topical 48-H Release Formulation as an Anti-scarring Treatment for Deep Partial-Thickness Burns
|
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Published in |
AAPS PharmSciTech, May 2018
|
DOI | 10.1208/s12249-018-1030-3 |
Pubmed ID | |
Authors |
Rossella Dorati, Jorge L. Medina, Patrick P. DeLuca, Kai P. Leung |
Abstract |
The purpose of this study was to develop pirfenidone (PF) ointment formulations for a dose finding study in the prophylactic treatment of deep partial-thickness burns in a mouse model. A preformulation study was performed to evaluate the solubility of PF in buffers and different solvents and its stability. Three different formulations containing 1, 3.5, and 6.5% w/w PF were prepared and optimized for their composition for testing in mice. Optimized formulations showed promising in vitro release profiles, in which 20-45% of PF was released in the first 7 h and 70-90% released within 48 h. The rheological properties of the ointment remained stable throughout storage at 25 ± 2°C/60% RH. Animal studies showed treatments of burn wounds during the inflammatory stage of wound healing with PF ointments at different drug concentrations had no adverse effects on reepithelization. Moreover, 6.5% PF ointment (F3) reduced the expression of pro-inflammatory cytokines IL-12p70 and TNFα. This study suggests that hydrocarbon base ointment could be a promising dosage form for topical delivery of PF in treatment of deep partial-thickness burns. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 34 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 4 | 12% |
Student > Bachelor | 3 | 9% |
Researcher | 2 | 6% |
Student > Postgraduate | 2 | 6% |
Student > Ph. D. Student | 2 | 6% |
Other | 5 | 15% |
Unknown | 16 | 47% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 6 | 18% |
Biochemistry, Genetics and Molecular Biology | 3 | 9% |
Medicine and Dentistry | 3 | 9% |
Chemistry | 3 | 9% |
Immunology and Microbiology | 1 | 3% |
Other | 2 | 6% |
Unknown | 16 | 47% |