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A Circulating MicroRNA Signature as a Biomarker for Prostate Cancer in a High Risk Group

Overview of attention for article published in Journal of Clinical Medicine, July 2015
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  • Good Attention Score compared to outputs of the same age (71st percentile)
  • High Attention Score compared to outputs of the same age and source (87th percentile)

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69 Mendeley
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Title
A Circulating MicroRNA Signature as a Biomarker for Prostate Cancer in a High Risk Group
Published in
Journal of Clinical Medicine, July 2015
DOI 10.3390/jcm4071369
Pubmed ID
Authors

Brian D. Kelly, Nicola Miller, Karl J. Sweeney, Garrett C. Durkan, Eamon Rogers, Killian Walsh, Michael J. Kerin

Abstract

Mi(cro)RNAs are small non-coding RNAs whose differential expression in tissue has been implicated in the development and progression of many malignancies, including prostate cancer. The discovery of miRNAs in the blood of patients with a variety of malignancies makes them an ideal, novel biomarker for prostate cancer diagnosis. The aim of this study was to identify a unique expression profile of circulating miRNAs in patients with prostate cancer attending a rapid access prostate assessment clinic. To conduct this study blood and tissue samples were collected from 102 patients (75 with biopsy confirmed cancer and 27 benign samples) following ethical approval and informed consent. These patients were attending a prostate assessment clinic. Samples were reverse-transcribed using stem-loop primers and expression levels of each of 12 candidate miRNAs were determined using real-time quantitative polymerase chain reaction. miRNA expression levels were then correlated with clinicopathological data and subsequently analysed using qBasePlus software and Minitab. Circulating miRNAs were detected and quantified in all subjects. The analysis of miRNA mean expression levels revealed that four miRNAs were significantly dysregulated, including let-7a (p = 0.005) which has known tumour suppressor characteristics, along with miR-141 (p = 0.01) which has oncogenic characteristics. In 20 patients undergoing a radical retropubic-prostatectomy, the expression levels of miR-141 returned to normal at day 10 post-operatively. A panel of four miRNAs could be used in combination to detect prostate cancer with an area under the curve (AUC) of 0.783 and a PPV of 80%. These findings identify a unique expression profile of miRNA detectable in the blood of prostate cancer patients. This confirms their use as a novel, diagnostic biomarker for prostate cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 2 3%
United States 1 1%
Russia 1 1%
Unknown 65 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 19%
Student > Master 10 14%
Student > Bachelor 9 13%
Researcher 8 12%
Student > Postgraduate 6 9%
Other 9 13%
Unknown 14 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 20 29%
Medicine and Dentistry 11 16%
Agricultural and Biological Sciences 8 12%
Chemistry 4 6%
Engineering 2 3%
Other 6 9%
Unknown 18 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 May 2017.
All research outputs
#6,750,808
of 23,906,448 outputs
Outputs from Journal of Clinical Medicine
#3,366
of 13,662 outputs
Outputs of similar age
#75,636
of 265,425 outputs
Outputs of similar age from Journal of Clinical Medicine
#5
of 31 outputs
Altmetric has tracked 23,906,448 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 13,662 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.1. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 265,425 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 31 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.