↓ Skip to main content

The effects of dorzolamide on choroidal and retinal perfusion in non-exudative age related macular degeneration

Overview of attention for article published in British Journal of Ophthalmology, June 2003
Altmetric Badge

Mentioned by

patent
3 patents

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
12 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
The effects of dorzolamide on choroidal and retinal perfusion in non-exudative age related macular degeneration
Published in
British Journal of Ophthalmology, June 2003
DOI 10.1136/bjo.87.6.753
Pubmed ID
Authors

A Harris, T A Ciulla, L M Pratt, E Rechtman, L Kagemann, H C Piper, H J Garzozi

Abstract

To comprehensively evaluate the effects of dorzolamide on the choroidal and retinal circulation in patients with age related macular degeneration (AMD). In this randomised, double masked, parallel study, 36 non-exudative AMD patients were randomised in a 2 to 1 fashion to placebo versus topical dorzolamide and underwent assessment of their choroidal and retinal circulation. Scanning laser ophthalmoscope indocyanine green angiograms (ICGA) were analysed by a new area dilution analysis technique. Four areas in the perifoveal region and two areas in the temporal peripapillary region were evaluated by plotting intensity of fluorescence of each area over time. The means of the choroidal filling times and the heterogeneity of the filling times were assessed. Scanning laser ophthalmoscope fluorescein angiography (FA) was evaluated for retinal arteriovenous passage (AVP) times by plotting intensity of fluorescence of retinal vessels over time. Assessment was performed at baseline and at 4 months. Compared to placebo, AMD patients treated with dorzolamide showed a significantly increased rapidity of choroidal filling in the superior and inferior peripapillary regions (p=0.007, p=0.02, respectively). No significant difference in choroidal filling times was found in any of the perifoveal areas (p=0.9). Also, on FA assessment, treatment with dorzolamide showed no statistical differences in AVP times (p=0.19). Dorzolamide may increase peripapillary choroidal perfusion in non-exudative AMD patients. Further studies are merited.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 8%
Unknown 11 92%

Demographic breakdown

Readers by professional status Count As %
Other 2 17%
Student > Doctoral Student 2 17%
Student > Master 2 17%
Student > Bachelor 1 8%
Student > Ph. D. Student 1 8%
Other 3 25%
Unknown 1 8%
Readers by discipline Count As %
Medicine and Dentistry 6 50%
Agricultural and Biological Sciences 1 8%
Philosophy 1 8%
Sports and Recreations 1 8%
Computer Science 1 8%
Other 0 0%
Unknown 2 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2017.
All research outputs
#8,534,976
of 25,374,647 outputs
Outputs from British Journal of Ophthalmology
#1,984
of 6,047 outputs
Outputs of similar age
#18,501
of 53,649 outputs
Outputs of similar age from British Journal of Ophthalmology
#8
of 25 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,047 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one is in the 44th percentile – i.e., 44% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 53,649 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.