Title |
Suppression of inflammation by helminths: a role for the gut microbiota?
|
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Published in |
Philosophical Transactions of the Royal Society B: Biological Sciences, August 2015
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DOI | 10.1098/rstb.2014.0296 |
Pubmed ID | |
Authors |
Paul Giacomin, John Croese, Lutz Krause, Alex Loukas, Cinzia Cantacessi |
Abstract |
Multiple recent investigations have highlighted the promise of helminth-based therapies for the treatment of inflammatory disorders of the intestinal tract of humans, including inflammatory bowel disease and coeliac disease. However, the mechanisms by which helminths regulate immune responses, leading to the amelioration of symptoms of chronic inflammation are unknown. Given the pivotal roles of the intestinal microbiota in the pathogenesis of these disorders, it has been hypothesized that helminth-induced modifications of the gut commensal flora may be responsible for the therapeutic properties of gastrointestinal parasites. In this article, we review recent progress in the elucidation of host-parasite-microbiota interactions in both animal models of chronic inflammation and humans, and provide a working hypothesis of the role of the gut microbiota in helminth-induced suppression of inflammation. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 13% |
Italy | 1 | 13% |
Spain | 1 | 13% |
Unknown | 5 | 63% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 8 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | <1% |
Denmark | 1 | <1% |
Poland | 1 | <1% |
Germany | 1 | <1% |
Unknown | 167 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 40 | 23% |
Student > Ph. D. Student | 30 | 18% |
Student > Bachelor | 24 | 14% |
Student > Master | 21 | 12% |
Professor | 11 | 6% |
Other | 17 | 10% |
Unknown | 28 | 16% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 46 | 27% |
Immunology and Microbiology | 24 | 14% |
Biochemistry, Genetics and Molecular Biology | 23 | 13% |
Medicine and Dentistry | 17 | 10% |
Veterinary Science and Veterinary Medicine | 6 | 4% |
Other | 23 | 13% |
Unknown | 32 | 19% |