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Prediction of Response to Cardiac Resynchronization Therapy Combining Two Different Three-Dimensional Analyses of Left Ventricular Dyssynchrony

Overview of attention for article published in American Journal of Cardiology, June 2011
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Title
Prediction of Response to Cardiac Resynchronization Therapy Combining Two Different Three-Dimensional Analyses of Left Ventricular Dyssynchrony
Published in
American Journal of Cardiology, June 2011
DOI 10.1016/j.amjcard.2011.04.023
Pubmed ID
Authors

Dominique Auger, Matteo Bertini, Nina Ajmone Marsan, Ulas Hoke, See H. Ewe, Joep Thijssen, Tomasz G. Witkowski, Kai-Hang Yiu, Arnold C.T. Ng, Ernst E. van der Wall, Martin J. Schalij, Jeroen J. Bax, Victoria Delgado

Abstract

Triplane tissue synchronization imaging (TSI) and real-time 3-dimensional echocardiography (RT3DE) provide different characterizations of left ventricular (LV) mechanics and dyssynchrony. Triplane TSI assesses differences in time to peak systolic segmental myocardial tissue velocities, whereas RT3DE evaluates differences in time to minimum end-systolic regional volumes. Whether an approach using the 2 3D techniques predicts better significant reverse remodeling after cardiac resynchronization therapy (CRT) remains unknown. In 166 patients (mean age 66 ± 9 years, 78% men) treated with CRT, baseline LV dyssynchrony was assessed using RT3DE and triplane TSI. LV dyssynchrony was defined by a systolic dyssynchrony index ≥6.4% when assessed with RT3DE and SD of time to peak velocity of 12 segments (Ts-SD-12) ≥33 ms with triplane TSI. CRT response was defined by ≥15% decrease in LV end-systolic volume at 6-month follow-up. Mean LV dyssynchrony using Ts-SD-12 was 48 ± 26 ms and mean systolic dyssynchrony index was 8.51 ± 3.81%. Response to CRT was observed in 86.3% of patients showing LV dyssynchrony with the 2 methods. In contrast, 97% of patients who did not show significant LV dyssynchrony with any of the techniques were nonresponders (p <0.001). Importantly, systolic dyssynchrony index and LV dyssynchrony using Ts-SD-12 were independent predictors of response to CRT (p <0.001 for each technique). Assessment of LV dyssynchrony with the 2 techniques showed incremental value for prediction of significant LV reverse remodeling over its assessment with only 1 technique (chi-square 90.18, p <0.001). In conclusion, the combined use of 2 different 3D techniques to assess LV dyssynchrony permits accurate prediction of response to CRT.

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The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 7%
Unknown 26 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 32%
Other 4 14%
Researcher 4 14%
Student > Master 3 11%
Student > Bachelor 2 7%
Other 4 14%
Unknown 2 7%
Readers by discipline Count As %
Medicine and Dentistry 17 61%
Computer Science 4 14%
Engineering 3 11%
Unknown 4 14%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2011.
All research outputs
#19,918,696
of 25,374,917 outputs
Outputs from American Journal of Cardiology
#8,546
of 10,181 outputs
Outputs of similar age
#105,396
of 127,296 outputs
Outputs of similar age from American Journal of Cardiology
#50
of 68 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
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We're also able to compare this research output to 68 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.