| Title |
Effect of heat stimulation on viability and proteoglycan metabolism ofcultured chondrocytes: preliminary report
|
|---|---|
| Published in |
Journal of Orthopaedic Science, May 2003
|
| DOI | 10.1007/s10776-002-0643-2 |
| Pubmed ID | |
| Authors |
Tatsuya Hojo, Mikihiro Fujioka, Goro Otsuka, Shigehiro Inoue, Ucchoru Kim, Toshikazu Kubo |
| Abstract |
Thermotherapy has been applied to various joint diseases and injuries, but its direct effects on articular cartilage have remained unclear. The present study examined the effects on cell viability and metabolism by using the chondrocyte-like cell line HCS-2/8. The temperatures and durations of heat stimulation were 39 degrees, 41 degrees, 43 degrees, and 45 degrees C for 15 or 30 min. After heat stimulation of 41 degrees C or lower for 15 or 30 min, cell viability increased and proteoglycan metabolism was accelerated, whereas after stimulation at 43 degrees C or higher for 30 min the viability and metabolism decreased. These results indicate that appropriate heat stimulation positively affects cell viability and the proteoglycan metabolism of articular cartilage, whereas too much heat stimulation produces negative effects. Clinical efficacy is therefore determined by the overall thermal dose. When the appropriate combination of temperature and duration is found, thermotherapy for diseases and injury of articular cartilage can be highly useful in clinical practice. |
Mendeley readers
The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 15 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 33% |
| Student > Postgraduate | 2 | 13% |
| Professor > Associate Professor | 2 | 13% |
| Student > Doctoral Student | 1 | 7% |
| Student > Bachelor | 1 | 7% |
| Other | 4 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 5 | 33% |
| Agricultural and Biological Sciences | 3 | 20% |
| Biochemistry, Genetics and Molecular Biology | 3 | 20% |
| Medicine and Dentistry | 3 | 20% |
| Immunology and Microbiology | 1 | 7% |
| Other | 0 | 0% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 January 2015.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Journal of Orthopaedic Science
#169
of 1,003 outputs
Outputs of similar age
#18,826
of 54,885 outputs
Outputs of similar age from Journal of Orthopaedic Science
#3
of 5 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,003 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 54,885 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 5 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.