| Title |
Migraine pain: reflections against vasodilatation
|
|---|---|
| Published in |
The Journal of Headache and Pain, June 2009
|
| DOI | 10.1007/s10194-009-0130-6 |
| Pubmed ID | |
| Authors |
Alessandro Panconesi, Maria Letizia Bartolozzi, Leonello Guidi |
| Abstract |
The original Wolff's vascular theory of migraine was supported by the discovery of a class of drugs, the triptans, developed as a selective cephalic vasoconstrictor agents. Even in the neurovascular hypothesis of Moskowitz, that is the neurogenic inflammation of meningeal vessels provoked by peptides released from trigeminal sensory neurons, the vasodilatation provoked by calcitonin gene-related peptide (CGRP) is considered today much more important than oedema. The role of cephalic vasodilatation as a cause of migraine pain was recently sustained by studies showing the therapeutic effect of CGRP receptor antagonists. We discuss the evidence against vasodilatation as migraine pain generator and some findings which we suggest in support of a central (brain) origin of pain. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 2% |
| Unknown | 45 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 12 | 26% |
| Student > Ph. D. Student | 9 | 20% |
| Researcher | 7 | 15% |
| Other | 4 | 9% |
| Professor > Associate Professor | 3 | 7% |
| Other | 7 | 15% |
| Unknown | 4 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 35% |
| Agricultural and Biological Sciences | 9 | 20% |
| Neuroscience | 4 | 9% |
| Nursing and Health Professions | 2 | 4% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 9 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2023.
All research outputs
#7,611,092
of 23,849,058 outputs
Outputs from The Journal of Headache and Pain
#691
of 1,417 outputs
Outputs of similar age
#38,923
of 116,367 outputs
Outputs of similar age from The Journal of Headache and Pain
#2
of 8 outputs
Altmetric has tracked 23,849,058 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,417 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.6. This one has gotten more attention than average, scoring higher than 50% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 116,367 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.