| Title |
Kv7 channels are upregulated during striatal neuron development and promote maturation of human iPSC-derived neurons
|
|---|---|
| Published in |
Pflügers Archiv - European Journal of Physiology, May 2018
|
| DOI | 10.1007/s00424-018-2155-7 |
| Pubmed ID | |
| Authors |
Vsevolod Telezhkin, Marco Straccia, Polina Yarova, Monica Pardo, Sun Yung, Ngoc-Nga Vinh, Jane M. Hancock, Gerardo Garcia-Diaz Barriga, David A. Brown, Anne E. Rosser, Jonathan T. Brown, Josep M. Canals, Andrew D. Randall, Nicholas D. Allen, Paul J. Kemp |
| Abstract |
Kv7 channels determine the resting membrane potential of neurons and regulate their excitability. Even though dysfunction of Kv7 channels has been linked to several debilitating childhood neuronal disorders, the ontogeny of the constituent genes, which encode Kv7 channels (KNCQ), and expression of their subunits have been largely unexplored. Here, we show that developmentally regulated expression of specific KCNQ mRNA and Kv7 channel subunits in mouse and human striatum is crucial to the functional maturation of mouse striatal neurons and human-induced pluripotent stem cell-derived neurons. This demonstrates their pivotal role in normal development and maturation, the knowledge of which can now be harnessed to synchronise and accelerate neuronal differentiation of stem cell-derived neurons, enhancing their utility for disease modelling and drug discovery. |
X Demographics
The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 4 | 44% |
| Belgium | 1 | 11% |
| Unknown | 4 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 6 | 67% |
| Scientists | 2 | 22% |
| Science communicators (journalists, bloggers, editors) | 1 | 11% |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 25% |
| Student > Bachelor | 4 | 13% |
| Researcher | 4 | 13% |
| Student > Master | 3 | 9% |
| Professor | 2 | 6% |
| Other | 5 | 16% |
| Unknown | 6 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 19% |
| Neuroscience | 6 | 19% |
| Agricultural and Biological Sciences | 5 | 16% |
| Medicine and Dentistry | 5 | 16% |
| Business, Management and Accounting | 1 | 3% |
| Other | 3 | 9% |
| Unknown | 6 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2018.
All research outputs
#4,751,341
of 23,815,455 outputs
Outputs from Pflügers Archiv - European Journal of Physiology
#207
of 1,973 outputs
Outputs of similar age
#89,315
of 331,801 outputs
Outputs of similar age from Pflügers Archiv - European Journal of Physiology
#1
of 24 outputs
Altmetric has tracked 23,815,455 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,973 research outputs from this source. They receive a mean Attention Score of 5.0. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,801 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 24 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.