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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antibody Signatures Reflect Different Disease Pathologies in Patients With Schistosomiasis Due to Schistosoma japonicum
|
|---|---|
| Published in |
Journal of Infectious Diseases, July 2015
|
| DOI | 10.1093/infdis/jiv356 |
| Pubmed ID | |
| Authors |
Patrick Driguez, Yuesheng Li, Soraya Gaze, Mark S. Pearson, Rie Nakajima, Angela Trieu, Denise L. Doolan, Philip L. Felgner, Xunya Hou, Fernanda C. Cardoso, Algis Jasinskas, Geoffrey N. Gobert, Alex Loukas, Donald P. McManus |
| Abstract |
Infection with Schistosoma japonicum causes high levels of pathology that is predominantly determined by the cellular and humoral response of the host. However, the specific antibody response that arises during the development of disease is largely undescribed in Asian schistosomiasis-endemic populations. Using a schistosome protein microarray the antibody profiles of high-pathology acute and advanced subjects, and low-pathology chronic and stool egg-negative individuals were compared with non-exposed controls. Immunodominant antigens (25) were identified that included vaccine candidates, tetraspanin-related proteins, transporter molecules and unannotated proteins. Additionally, high-pathology individuals had a limited specific antibody response suggesting that low-pathology individuals may use a broad and strong antibody response, particularly against surface-exposed proteins, to control pathology and/or infection. Our study has identified specific antigens that can discriminate between S. japonicum-exposed groups with different pathologies, and may also allow the host to control disease pathology and provide resistance to parasite infection. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 27 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 4% |
| Australia | 1 | 4% |
| Unknown | 25 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 19% |
| Researcher | 4 | 15% |
| Student > Master | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Librarian | 2 | 7% |
| Other | 6 | 22% |
| Unknown | 5 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 30% |
| Medicine and Dentistry | 6 | 22% |
| Immunology and Microbiology | 3 | 11% |
| Biochemistry, Genetics and Molecular Biology | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 5 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 May 2016.
All research outputs
#20,657,128
of 25,377,790 outputs
Outputs from Journal of Infectious Diseases
#13,625
of 14,793 outputs
Outputs of similar age
#201,825
of 276,229 outputs
Outputs of similar age from Journal of Infectious Diseases
#99
of 117 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 14,793 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.4. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,229 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 117 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.