Title |
Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase
|
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Published in |
Proceedings of the Japan Academy, Series B: Physical and Biological Sciences, January 2017
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DOI | 10.2183/pjab.93.027 |
Pubmed ID | |
Authors |
Yousuke FURUTA, Takashi KOMENO, Takaaki NAKAMURA |
Abstract |
Favipiravir (T-705; 6-fluoro-3-hydroxy-2-pyrazinecarboxamide) is an anti-viral agent that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRp) of RNA viruses. Favipiravir was discovered through screening chemical library for anti-viral activity against the influenza virus by Toyama Chemical Co., Ltd. Favipiravir undergoes an intracellular phosphoribosylation to be an active form, favipiravir-RTP (favipiravir ribofuranosyl-5'-triphosphate), which is recognized as a substrate by RdRp, and inhibits the RNA polymerase activity. Since the catalytic domain of RdRp is conserved among various types of RNA viruses, this mechanism of action underpins a broader spectrum of anti-viral activities of favipiravir. Favipiravir is effective against a wide range of types and subtypes of influenza viruses, including strains resistant to existing anti-influenza drugs. Of note is that favipiravir shows anti-viral activities against other RNA viruses such as arenaviruses, bunyaviruses and filoviruses, all of which are known to cause fatal hemorrhagic fever. These unique anti-viral profiles will make favipiravir a potentially promising drug for specifically untreatable RNA viral infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 30 | 14% |
Japan | 8 | 4% |
Canada | 5 | 2% |
India | 5 | 2% |
Austria | 4 | 2% |
France | 3 | 1% |
Spain | 2 | <1% |
Germany | 2 | <1% |
United Kingdom | 2 | <1% |
Other | 22 | 10% |
Unknown | 129 | 61% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 181 | 85% |
Scientists | 17 | 8% |
Practitioners (doctors, other healthcare professionals) | 9 | 4% |
Science communicators (journalists, bloggers, editors) | 5 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 743 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 95 | 13% |
Student > Bachelor | 90 | 12% |
Student > Master | 83 | 11% |
Researcher | 57 | 8% |
Other | 38 | 5% |
Other | 127 | 17% |
Unknown | 253 | 34% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 92 | 12% |
Pharmacology, Toxicology and Pharmaceutical Science | 91 | 12% |
Medicine and Dentistry | 79 | 11% |
Chemistry | 51 | 7% |
Agricultural and Biological Sciences | 38 | 5% |
Other | 107 | 14% |
Unknown | 285 | 38% |