Title |
Lower Cerebrospinal Fluid Concentration of Brain-Derived Neurotrophic Factor Predicts Progression from Mild Cognitive Impairment to Alzheimer’s Disease
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Published in |
NeuroMolecular Medicine, July 2015
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DOI | 10.1007/s12017-015-8361-y |
Pubmed ID | |
Authors |
Orestes Vicente Forlenza, Breno Satler Diniz, Antonio Lucio Teixeira, Marcia Radanovic, Leda Leme Talib, Natalia Pessoa Rocha, Wagner Farid Gattaz |
Abstract |
There is little information on the dynamics of BDNF in the CSF in the continuum between healthy aging, MCI and AD. We included 128 older adults (77 with amnestic MCI, 26 with AD and 25 healthy controls). CSF BDNF level was measured by ELISA assay, and AD biomarkers (Aβ42, T-Tau and P-Tau181) were measured using a Luminex xMAP assay. CSF BDNF levels were significantly reduced in AD subjects compared to MCI and healthy controls (p = 0.009). Logistic regression models showed that lower CSF BDNF levels (p = 0.008), lower CSF Aβ42 (p = 0.005) and lower MMSE scores (p = 0.007) are significantly associated with progression from MCI to AD. The present study adds strong evidence of the involvement of BDNF in the pathophysiology of neurodegenerative changes in AD. Interventions aiming to restore central neurotrophic support may represent future therapeutic targets to prevent or delay the progression from MCI to AD. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
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United Kingdom | 1 | 1% |
Unknown | 93 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 19 | 20% |
Student > Master | 13 | 14% |
Researcher | 11 | 12% |
Student > Doctoral Student | 8 | 9% |
Professor | 6 | 6% |
Other | 23 | 24% |
Unknown | 14 | 15% |
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Neuroscience | 19 | 20% |
Psychology | 11 | 12% |
Agricultural and Biological Sciences | 10 | 11% |
Nursing and Health Professions | 5 | 5% |
Other | 14 | 15% |
Unknown | 16 | 17% |