Title |
Isoleucine or valine deprivation stimulates fat loss via increasing energy expenditure and regulating lipid metabolism in WAT
|
---|---|
Published in |
Amino Acids, October 2011
|
DOI | 10.1007/s00726-011-1123-8 |
Pubmed ID | |
Authors |
Ying Du, Qingshu Meng, Qian Zhang, Feifan Guo |
Abstract |
There has been a growing interest in controlling body weight by increasing dietary levels of leucine recently. By contrast, we have focused on studying the effect of deficiency of branched-chain amino acids (BCAAs) leucine on lipid metabolism. We previously have shown that mice fed a leucine-deficient diet for 7 days exhibit significant changes in lipid metabolism as demonstrated by suppressed lipogenesis in the liver and increased fat mobilization in white adipose tissue, the latter of which was found to be caused by increased lipolysis in WAT and uncoupling protein 1 expression in brown adipose tissue. The goal of our current study is to investigate whether the above effects of leucine deficiency can be generalized to the deficiency of other BCAAs including valine and isoleucine. In our current study, we show that valine or isoleucine deficiency has similar effects on reducing fat mass to leucine deprivation, in a similar manner as those observed during leucine deprivation. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Practitioners (doctors, other healthcare professionals) | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Luxembourg | 1 | 2% |
Unknown | 58 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 12 | 20% |
Student > Master | 10 | 17% |
Student > Ph. D. Student | 10 | 17% |
Student > Bachelor | 6 | 10% |
Student > Doctoral Student | 3 | 5% |
Other | 3 | 5% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 20 | 34% |
Biochemistry, Genetics and Molecular Biology | 13 | 22% |
Medicine and Dentistry | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Veterinary Science and Veterinary Medicine | 1 | 2% |
Other | 2 | 3% |
Unknown | 19 | 32% |