| Title |
SIRTain regulators of premature senescence and accelerated aging
|
|---|---|
| Published in |
Protein & Cell, April 2015
|
| DOI | 10.1007/s13238-015-0149-1 |
| Pubmed ID | |
| Authors |
Shrestha Ghosh, Zhongjun Zhou |
| Abstract |
The sirtuin proteins constitute class III histone deacetylases (HDACs). These evolutionarily conserved NAD(+)-dependent enzymes form an important component in a variety of cellular and biological processes with highly divergent as well as convergent roles in maintaining metabolic homeostasis, safeguarding genomic integrity, regulating cancer metabolism and also inflammatory responses. Amongst the seven known mammalian sirtuin proteins, SIRT1 has gained much attention due to its widely acknowledged roles in promoting longevity and ameliorating age-associated pathologies. The contributions of other sirtuins in the field of aging are also gradually emerging. Here, we summarize some of the recent discoveries in sirtuins biology which clearly implicate the functions of sirtuin proteins in the regulation of premature cellular senescence and accelerated aging. The roles of sirtuins in various cellular processes have been extrapolated to draw inter-linkage with anti-aging mechanisms. Also, the latest findings on sirtuins which might have potential effects in the process of aging have been reviewed. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| United States | 1 | 2% |
| Unknown | 57 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 19% |
| Student > Ph. D. Student | 9 | 15% |
| Student > Doctoral Student | 9 | 15% |
| Student > Master | 8 | 14% |
| Other | 4 | 7% |
| Other | 11 | 19% |
| Unknown | 7 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 29% |
| Medicine and Dentistry | 12 | 20% |
| Agricultural and Biological Sciences | 10 | 17% |
| Immunology and Microbiology | 1 | 2% |
| Sports and Recreations | 1 | 2% |
| Other | 5 | 8% |
| Unknown | 13 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 48. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2023.
All research outputs
#772,222
of 23,539,593 outputs
Outputs from Protein & Cell
#28
of 769 outputs
Outputs of similar age
#10,041
of 266,446 outputs
Outputs of similar age from Protein & Cell
#4
of 16 outputs
Altmetric has tracked 23,539,593 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 769 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,446 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.