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Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes

Overview of attention for article published in Environmental Pollution, October 2011
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Title
Removal of the antiviral agent oseltamivir and its biological activity by oxidative processes
Published in
Environmental Pollution, October 2011
DOI 10.1016/j.envpol.2011.09.018
Pubmed ID
Authors

Hana Mestankova, Kristin Schirmer, Beate I. Escher, Urs von Gunten, Silvio Canonica

Abstract

The antiviral agent oseltamivir acid (OA, the active metabolite of Tamiflu(®)) may occur at high concentrations in wastewater during pandemic influenza events. To eliminate OA and its antiviral activity from wastewater, ozonation and advanced oxidation processes were investigated. For circumneutral pH, kinetic measurements yielded second-order rate constants of 1.7 ± 0.1 × 10(5) and 4.7 ± 0.2 × 10(9) M(-1) s(-1) for the reaction of OA with ozone and hydroxyl radical, respectively. During the degradation of OA by both oxidants, the antiviral activity of the treated aqueous solutions was measured by inhibition of neuraminidase activity of two different viral strains. A transient, moderate (two-fold) increase in antiviral activity was observed in solutions treated up to a level of 50% OA transformation, while for higher degrees of transformation the activity corresponded to that caused exclusively by OA. OA was efficiently removed by ozonation in a wastewater treatment plant effluent, suggesting that ozonation can be applied to remove OA from wastewater.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 1%
China 1 1%
Germany 1 1%
Unknown 64 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 17 25%
Professor > Associate Professor 6 9%
Student > Master 6 9%
Researcher 5 7%
Student > Postgraduate 4 6%
Other 13 19%
Unknown 16 24%
Readers by discipline Count As %
Environmental Science 12 18%
Chemistry 12 18%
Chemical Engineering 7 10%
Engineering 7 10%
Biochemistry, Genetics and Molecular Biology 3 4%
Other 8 12%
Unknown 18 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 October 2011.
All research outputs
#17,285,668
of 25,374,647 outputs
Outputs from Environmental Pollution
#6,978
of 13,433 outputs
Outputs of similar age
#105,909
of 152,385 outputs
Outputs of similar age from Environmental Pollution
#30
of 35 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,433 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 152,385 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 35 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.