| Title |
Effect of levosimendan in patients with acute decompensated heart failure
|
|---|---|
| Published in |
Herz, April 2018
|
| DOI | 10.1007/s00059-018-4693-3 |
| Pubmed ID | |
| Authors |
S. Zhou, L. Zhang, J. Li |
| Abstract |
Acute decompensated heart failure (ADHF) is associated with high morbidity and mortality. Intravenous inotropic agents play an important role in treating ADHF. Relatively small clinical studies have evaluated the effects of levosimendan, a positive inotropic agent with calcium-sensitizing effects, in ADHF. The present meta-analysis pooled these studies to assess the clinical efficacy of levosimendan in ADHF. The PubMed, MEDLINE, Cochrane Library, and ClinicalTrials.com databases were systematically searched for prospective clinical studies published in English up to May 2017 on effects of levosimendan alone or versus other agents (placebo [glucose], dopamine, furosemide) on left ventricular ejection fraction (LVEF), brain natriuretic peptide (BNP) level, and heart rate (HR) in patients with ADHF. Seven articles were selected with 132 patients for levosimendan and 125 patients for control groups. Compared with controls (except dopamine) or after vs. before use, levosimendan was associated with a significantly reduced BNP level (standardized mean difference [SMD]: -0.70; 95% confidence interval [CI]: -0.92, -0.48; p = 0.000; I2 = 22.0%), as well as improved LVEF (SMD: 0.47; 95%CI: 0.12, 0.81; p = 0.008; I2 = 63.3%) and increased HR (SMD: 0.39; 95% CI: 0.15, 0.63; p = 0.002; I2 = 23.6%) when comparing after vs. before use but not in comparisons to controls. In the present meta-analysis, levosimendan infusion in patients with ADHF appeared to reduce BNP regardless of the comparator (except for dopamine), and also improve LVEF and increase HR in after vs. before use comparisons but not compared to controls. Future larger studies on the benefit of levosimendan in ADHF patients are warranted. |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 3 | 18% |
| Researcher | 2 | 12% |
| Student > Master | 2 | 12% |
| Student > Doctoral Student | 1 | 6% |
| Student > Ph. D. Student | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 6 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 59% |
| Nursing and Health Professions | 1 | 6% |
| Unknown | 6 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2018.
All research outputs
#20,509,310
of 23,075,872 outputs
Outputs from Herz
#376
of 444 outputs
Outputs of similar age
#290,511
of 329,354 outputs
Outputs of similar age from Herz
#4
of 4 outputs
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