| Title |
Dose and Timing of Prenatal Alcohol Exposure and Maternal Nutritional Supplements: Developmental Effects on 6-Month-Old Infants
|
|---|---|
| Published in |
Maternal and Child Health Journal, July 2015
|
| DOI | 10.1007/s10995-015-1779-x |
| Pubmed ID | |
| Authors |
Claire D. Coles, Julie A. Kable, Carl L. Keen, Kenneth Lyons Jones, Wladimir Wertelecki, Irina V. Granovska, Alla O. Pashtepa, Christina D. Chambers, the CIFASD |
| Abstract |
Fetal alcohol spectrum disorders are more common in disadvantaged populations. Environmental factors, like suboptimal nutrition, may potentiate the developmental effects of prenatal alcohol exposure. To evaluate the impact of micronutrients, including choline, on reduction of effects of exposure, we examined timing and dose of alcohol and effects of nutritional supplementation at two OMNI-Net sites in Western Ukraine that included high and low risk individuals. Alcohol-using and nondrinking women were randomized to one of three multivitamin/mineral supplement groups: none, multivitamins/minerals (MVM), and multivitamin/minerals plus choline. Children (N = 367) were tested at 6 months with the Bayley Scales of Infant Development (2nd ED) yielding standard scores for Mental Development Index (MDI), Psychomotor Development Index (PDI) and Behavior. Generalized linear modeling was used: (1) for factorial analysis of effects of alcohol group, multivitamin/minerals, and choline supplementation; and (2) to examine the relationship between amount and timing of alcohol (ounces of absolute alcohol/day [ozAA/day] peri-conception and on average in the second trimester) and MVM supplementation on developmental outcomes while controlling sex, social class, and smoking. MDI was significantly impacted by peri-conceptual alcohol dose ([Formula: see text], p < .001) with more alcohol associated with lower scores and males more negatively affected than females ([Formula: see text], p < .002). Micronutrient supplementation had a protective effect; those receiving supplements performed better ([Formula: see text], p < .005). The PDI motor scores did not differ by group but were affected by peri-conceptual alcohol dose ([Formula: see text], p < .04). Multivitamin/mineral supplementation can reduce the negative impact of alcohol use during pregnancy on specific developmental outcomes. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 203 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 201 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 14% |
| Student > Master | 29 | 14% |
| Researcher | 26 | 13% |
| Student > Bachelor | 18 | 9% |
| Professor > Associate Professor | 11 | 5% |
| Other | 29 | 14% |
| Unknown | 61 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 40 | 20% |
| Psychology | 22 | 11% |
| Neuroscience | 14 | 7% |
| Nursing and Health Professions | 13 | 6% |
| Social Sciences | 10 | 5% |
| Other | 35 | 17% |
| Unknown | 69 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 March 2017.
All research outputs
#6,838,548
of 23,906,448 outputs
Outputs from Maternal and Child Health Journal
#671
of 2,039 outputs
Outputs of similar age
#76,707
of 265,885 outputs
Outputs of similar age from Maternal and Child Health Journal
#18
of 39 outputs
Altmetric has tracked 23,906,448 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,039 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.2. This one has gotten more attention than average, scoring higher than 64% of its peers.
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We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.