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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transcriptional Regulation of the p16 Tumor Suppressor Gene.
|
|---|---|
| Published in |
Anticancer Research: International Journal of Cancer Research and Treatment, August 2015
|
| Pubmed ID | |
| Authors |
Yojiro Kotake, Madoka Naemura, Chihiro Murasaki, Yasutoshi Inoue, Haruna Okamoto |
| Abstract |
The p16 tumor suppressor gene encodes a specific inhibitor of cyclin-dependent kinase (CDK) 4 and 6 and is found altered in a wide range of human cancers. p16 plays a pivotal role in tumor suppressor networks through inducing cellular senescence that acts as a barrier to cellular transformation by oncogenic signals. p16 protein is relatively stable and its expression is primary regulated by transcriptional control. Polycomb group (PcG) proteins associate with the p16 locus in a long non-coding RNA, ANRIL-dependent manner, leading to repression of p16 transcription. YB1, a transcription factor, also represses the p16 transcription through direct association with its promoter region. Conversely, the transcription factors Ets1/2 and histone H3K4 methyltransferase MLL1 directly bind to the p16 locus and mediate p16 induction during replicative and premature senescence. In the present review, we discuss the molecular mechanisms by which these factors regulate p16 transcription. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 103 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | <1% |
| Canada | 1 | <1% |
| Unknown | 101 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 30% |
| Researcher | 16 | 16% |
| Student > Master | 15 | 15% |
| Student > Bachelor | 10 | 10% |
| Student > Doctoral Student | 5 | 5% |
| Other | 13 | 13% |
| Unknown | 13 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 39 | 38% |
| Agricultural and Biological Sciences | 24 | 23% |
| Medicine and Dentistry | 14 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Neuroscience | 3 | 3% |
| Other | 6 | 6% |
| Unknown | 13 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 March 2024.
All research outputs
#3,242,827
of 25,494,370 outputs
Outputs from Anticancer Research: International Journal of Cancer Research and Treatment
#173
of 4,030 outputs
Outputs of similar age
#39,536
of 276,603 outputs
Outputs of similar age from Anticancer Research: International Journal of Cancer Research and Treatment
#3
of 83 outputs
Altmetric has tracked 25,494,370 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,030 research outputs from this source. They receive a mean Attention Score of 4.3. This one has done particularly well, scoring higher than 95% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,603 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 85% of its contemporaries.
We're also able to compare this research output to 83 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.