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The impact of calcium volume and distribution in aortic root injury related to balloon-expandable transcatheter aortic valve replacement

Overview of attention for article published in Journal of Cardiovascular Computed Tomography, April 2015
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  • High Attention Score compared to outputs of the same age and source (86th percentile)

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Title
The impact of calcium volume and distribution in aortic root injury related to balloon-expandable transcatheter aortic valve replacement
Published in
Journal of Cardiovascular Computed Tomography, April 2015
DOI 10.1016/j.jcct.2015.04.002
Pubmed ID
Authors

Nicolaj C. Hansson, Bjarne L. Nørgaard, Marco Barbanti, Niels Erik Nielsen, Tae-Hyun Yang, Corrado Tamburino, Danny Dvir, Hasan Jilaihawi, Phillip Blanke, Raj R. Makkar, Azeem Latib, Antonio Colombo, Giuseppe Tarantini, Rekha Raju, David Wood, Henning R. Andersen, Henrique B. Ribeiro, Samir Kapadia, James Min, Gudrun Feuchtner, Ronen Gurvitch, Faisal Alqoofi, Marc Pelletier, Gian Paolo Ussia, Massimo Napodano, Fabio Sandoli de Brito, Susheel Kodali, Gregor Pache, Sergio J. Canovas, Adam Berger, Darra Murphy, Lars G. Svensson, Josep Rodés-Cabau, Martin B. Leon, John G. Webb, Jonathon Leipsic

Abstract

A detailed assessment of calcium within the aortic root may provide important additional information regarding the risk of aortic root injury during transcatheter heart valve replacement (TAVR). We sought to delineate the effect of calcium volume and distribution on aortic root injury during TAVR. Thirty-three patients experiencing aortic root injury during TAVR with a balloon-expandable valve were compared with a control group of 153 consecutive TAVR patients without aortic root injury (as assessed by post-TAVR multidetector CT). Using commercial software to analyze contrast-enhanced pre-TAVR CT scans, calcium volume was determined in 3 regions: (1) the overall left ventricular outflow tract (LVOT), extending 10 mm down from the aortic annulus plane; (2) the upper LVOT, extending 2 mm down from the annulus plane; and (3) the aortic valve region. Calcium volumes in the upper LVOT (median, 29 vs 0 mm(3); P < .0001) and overall LVOT (median, 74 vs 3 mm(3); P = .0001) were higher in patients who experienced aortic root injury compared with the control group. Calcium in the aortic valve region did not differ between groups. Upper LVOT calcium volume was more predictive of aortic root injury than overall LVOT calcium volume (area under receiver operating curve [AUC], 0.78; 95% confidence interval, 0.69-0.86 vs AUC, 0.71; 95% confidence interval, 0.62-0.82; P = .010). Upper LVOT calcium below the noncoronary cusp was significantly more predictive of aortic root injury compared to calcium underneath the right coronary cusp or the left coronary cusp (AUC, 0.81 vs 0.68 vs 0.64). Prosthesis oversizing >20% (likelihood ratio test, P = .028) and redilatation (likelihood ratio test, P = .015) improved prediction of aortic root injury by upper LVOT calcium volume. Calcification of the LVOT, especially in the upper LVOT, located below the noncoronary cusp and extending from the annular region, is predictive of aortic root injury during TAVR with a balloon-expandable valve.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 106 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 20 19%
Other 11 10%
Student > Postgraduate 9 8%
Professor > Associate Professor 8 8%
Student > Ph. D. Student 7 7%
Other 17 16%
Unknown 34 32%
Readers by discipline Count As %
Medicine and Dentistry 52 49%
Agricultural and Biological Sciences 3 3%
Engineering 3 3%
Computer Science 3 3%
Mathematics 1 <1%
Other 4 4%
Unknown 40 38%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 August 2018.
All research outputs
#7,204,882
of 25,373,627 outputs
Outputs from Journal of Cardiovascular Computed Tomography
#412
of 917 outputs
Outputs of similar age
#79,869
of 279,688 outputs
Outputs of similar age from Journal of Cardiovascular Computed Tomography
#3
of 22 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one has received more attention than most of these and is in the 71st percentile.
So far Altmetric has tracked 917 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.3. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 279,688 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.