| Title |
Zein Microneedles for Localized Delivery of Chemotherapeutic Agents to Treat Breast Cancer: Drug Loading, Release Behavior, and Skin Permeation Studies
|
|---|---|
| Published in |
AAPS PharmSciTech, April 2018
|
| DOI | 10.1208/s12249-018-1004-5 |
| Pubmed ID | |
| Authors |
Shubhmita Bhatnagar, Pooja Kumari, Srijanaki Paravastu Pattarabhiran, Venkata Vamsi Krishna Venuganti |
| Abstract |
Localized delivery of chemotherapeutic agents to treat breast cancer could limit their adverse drug reactions. The aim of this study was to investigate the influence of physico-chemical properties of chemotherapeutic agents in their loading, release behavior, and skin permeation using microneedles. Zein microneedles were fabricated using the micromolding technique containing 36 microneedles in a 1-cm2 area. These microneedles were loaded with two anti-breast cancer drugs, tamoxifen and gemcitabine, having different water solubilities. Entrapment or surface coating of chemotherapeutic agents in zein microneedles was optimized to achieve greater loading efficiency. The greatest loading achieved was 607 ± 21 and 1459 ± 74 μg for tamoxifen and gemcitabine using the entrapment approach, respectively. Skin permeation studies in excised porcine skin showed that the coating on microneedles approach results in greater skin deposition for tamoxifen; while the poke-and-patch approach would provide greater skin permeation for gemcitabine. Taken together, it can be concluded that different loading strategies and skin penetration approaches have to be studied for delivery of small molecules using polymeric microneedles. |
Mendeley readers
The data shown below were compiled from readership statistics for 120 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 120 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 15% |
| Researcher | 14 | 12% |
| Student > Master | 10 | 8% |
| Student > Doctoral Student | 7 | 6% |
| Student > Bachelor | 5 | 4% |
| Other | 12 | 10% |
| Unknown | 54 | 45% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 34 | 28% |
| Engineering | 6 | 5% |
| Biochemistry, Genetics and Molecular Biology | 6 | 5% |
| Materials Science | 4 | 3% |
| Medicine and Dentistry | 4 | 3% |
| Other | 7 | 6% |
| Unknown | 59 | 49% |
Attention Score in Context
This research output has an Altmetric Attention Score of 23. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 May 2023.
All research outputs
#1,455,872
of 23,758,679 outputs
Outputs from AAPS PharmSciTech
#13
of 1,507 outputs
Outputs of similar age
#33,458
of 330,536 outputs
Outputs of similar age from AAPS PharmSciTech
#1
of 29 outputs
Altmetric has tracked 23,758,679 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 93rd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,507 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,536 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.