| Title |
An update on the role of the inflammasomes in the pathogenesis of kidney diseases
|
|---|---|
| Published in |
Pediatric Nephrology, July 2015
|
| DOI | 10.1007/s00467-015-3153-z |
| Pubmed ID | |
| Authors |
Murthy N. Darisipudi, Felix Knauf |
| Abstract |
Innate immune response pathways play a critical role as the first line of defense. Initiation of an immune response requires sensors that can detect noxious stimuli within the cellular microenvironment. Inflammasomes are signaling platforms that are assembled in response to both microbe-specific and nonmicrobial antigens. Upon activation, proinflammatory cytokines are released to engage immune defenses and to trigger an inflammatory cell death referred to as pyroptosis. The aim of this review is to provide an overview of the current knowledge of the role of the inflammasomes in the pathogenesis of kidney diseases. As crystal deposition in the kidney is a frequent cause of acute kidney injury and chronic kidney disease in children, recent insights into mechanisms of inflammasome activation by renal crystals are highlighted. This may be of particular interest to pediatric patients and nephrologists in need of new therapeutic approaches. Lastly, current data findings that inflammasomes are not only of major importance in host defense but are also a key regulator of the intestinal microbiota and the progression of systemic diseases are reviewed. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Ecuador | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 1% |
| United States | 1 | 1% |
| Unknown | 82 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 11 | 13% |
| Researcher | 10 | 12% |
| Student > Ph. D. Student | 9 | 11% |
| Student > Master | 9 | 11% |
| Unspecified | 8 | 10% |
| Other | 25 | 30% |
| Unknown | 12 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 21 | 25% |
| Biochemistry, Genetics and Molecular Biology | 11 | 13% |
| Unspecified | 9 | 11% |
| Nursing and Health Professions | 6 | 7% |
| Agricultural and Biological Sciences | 6 | 7% |
| Other | 19 | 23% |
| Unknown | 12 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 July 2015.
All research outputs
#14,818,555
of 22,817,213 outputs
Outputs from Pediatric Nephrology
#2,543
of 3,540 outputs
Outputs of similar age
#144,619
of 262,407 outputs
Outputs of similar age from Pediatric Nephrology
#20
of 55 outputs
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So far Altmetric has tracked 3,540 research outputs from this source. They receive a mean Attention Score of 4.9. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
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We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 54% of its contemporaries.