| Title |
Chronic Effects of Realistic Concentrations of Non-essential and Essential Metals (Lead and Zinc) on Oxidative Stress Biomarkers of the Mosquitofish, Gambusia holbrooki
|
|---|---|
| Published in |
Archives of Environmental Contamination and Toxicology, July 2015
|
| DOI | 10.1007/s00244-015-0190-3 |
| Pubmed ID | |
| Authors |
Bruno Nunes, Carina Caldeira, Joana Luísa Pereira, Fernando Gonçalves, Alberto Teodorico Correia |
| Abstract |
Metallic contamination is widespread, particularly in areas impacted by human activities. Human activities result in high loads of metals being discarded into the aquatic compartment, reinforcing the need to evaluate their toxic effects especially on exposed fish. The purpose of this study was to determine the toxic response (namely, antioxidant levels and lipoperoxidative damage) in both liver and gills of the freshwater fish species Gambusia holbrooki, exposed to lead and zinc. Fish were exposed for 28 days (chronic exposure) to ecologically relevant concentrations of the selected compounds. The following oxidative stress/damage biomarkers were evaluated: glutathione-S-transferases (GSTs), glutathione reductase (GR), and thiobarbituric acid reactive substances (TBARS). The results indicate that lead caused a significant oxidative response, with significant increase of the enzymatic antioxidant defense (GSTs activity in hepatic tissue, and GR activity in branchial tissue) of exposed organisms. On the other hand, zinc caused a significant inhibition of G. holbrooki hepatic GR, a biological response that may be related to the antioxidant activity exhibited by this metal. The obtained results are of high importance, especially if one considers that the obtained toxic responses occurred at low, albeit ecologically relevant, levels of exposure. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 3% |
| Belgium | 1 | 3% |
| Egypt | 1 | 3% |
| Unknown | 26 | 90% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 14% |
| Student > Doctoral Student | 4 | 14% |
| Student > Ph. D. Student | 4 | 14% |
| Other | 3 | 10% |
| Lecturer | 2 | 7% |
| Other | 6 | 21% |
| Unknown | 6 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Environmental Science | 8 | 28% |
| Agricultural and Biological Sciences | 6 | 21% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Veterinary Science and Veterinary Medicine | 1 | 3% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 9 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2015.
All research outputs
#18,541,858
of 23,806,312 outputs
Outputs from Archives of Environmental Contamination and Toxicology
#1,565
of 2,093 outputs
Outputs of similar age
#159,816
of 235,723 outputs
Outputs of similar age from Archives of Environmental Contamination and Toxicology
#28
of 54 outputs
Altmetric has tracked 23,806,312 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,093 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.6. This one is in the 21st percentile – i.e., 21% of its peers scored the same or lower than it.
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