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Mendeley readers
Attention Score in Context
| Title |
Identification of two new loci at IL23R and RAB32 that influence susceptibility to leprosy
|
|---|---|
| Published in |
Nature Genetics, October 2011
|
| DOI | 10.1038/ng.973 |
| Pubmed ID | |
| Authors |
Furen Zhang, Hong Liu, Shumin Chen, Huiqi Low, Liangdan Sun, Yong Cui, Tongsheng Chu, Yi Li, Xi'an Fu, Yongxiang Yu, Gongqi Yu, Benqing Shi, Hongqing Tian, Dianchang Liu, Xiulu Yu, Jinghui Li, Nan Lu, Fangfang Bao, Chunying Yuan, Jian Liu, Huaxu Liu, Lin Zhang, Yonghu Sun, Mingfei Chen, Qing Yang, Haitao Yang, Rongde Yang, Lianhua Zhang, Qiang Wang, Hong Liu, Fuguang Zuo, Haizhen Zhang, Chiea Chuen Khor, Martin L Hibberd, Sen Yang, Jianjun Liu, Xuejun Zhang |
| Abstract |
We performed a genome-wide association study with 706 individuals with leprosy and 5,581 control individuals and replicated the top 24 SNPs in three independent replication samples, including a total of 3,301 individuals with leprosy and 5,299 control individuals from China. Two loci not previously associated with the disease were identified with genome-wide significance: rs2275606 (combined P = 3.94 × 10(-14), OR = 1.30) on 6q24.3 and rs3762318 (combined P = 3.27 × 10(-11), OR = 0.69) on 1p31.3. These associations implicate IL23R and RAB32 as new susceptibility genes for leprosy. Furthermore, we identified evidence of interaction between the NOD2 and RIPK2 loci, which is consistent with the biological association of the proteins encoded by these genes (NOD2-RIPK2 complex) in activating the NF-κB pathway as a part of the host defense response to infection. Our findings have expanded the biological functions of IL23R by uncovering its involvement in infectious disease susceptibility and suggest a potential involvement of autophagocytosis in leprosy pathogenesis. The IL23R association supports previous observations of the marked overlap of susceptibility genes for leprosy and Crohn's disease, implying common pathogenesis mechanisms. |
Mendeley readers
The data shown below were compiled from readership statistics for 110 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 108 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 24% |
| Student > Ph. D. Student | 16 | 15% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 12 | 11% |
| Student > Doctoral Student | 8 | 7% |
| Other | 24 | 22% |
| Unknown | 11 | 10% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 32 | 29% |
| Biochemistry, Genetics and Molecular Biology | 30 | 27% |
| Medicine and Dentistry | 15 | 14% |
| Immunology and Microbiology | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 3% |
| Other | 8 | 7% |
| Unknown | 15 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2012.
All research outputs
#7,251,146
of 22,914,829 outputs
Outputs from Nature Genetics
#5,399
of 7,211 outputs
Outputs of similar age
#45,423
of 140,606 outputs
Outputs of similar age from Nature Genetics
#53
of 81 outputs
Altmetric has tracked 22,914,829 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 7,211 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 140,606 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.