Title |
A probable prehistoric case of meningococcal disease from San Francisco Bay: Next generation sequencing of Neisseria meningitidis from dental calculus and osteological evidence
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Published in |
International Journal of Paleopathology, May 2018
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DOI | 10.1016/j.ijpp.2018.05.001 |
Pubmed ID | |
Authors |
Jelmer W. Eerkens, Ruth V. Nichols, Gemma G.R. Murray, Katherine Perez, Engel Murga, Phil Kaijankoski, Jeffrey S. Rosenthal, Laurel Engbring, Beth Shapiro |
Abstract |
Next Generation Sequencing (NGS) of ancient dental calculus samples from a prehistoric site in San Francisco Bay, CA-SCL-919, reveals a wide range of potentially pathogenic bacteria. One older adult woman, in particular, had high levels of Neisseria meningitidis and low levels of Haemophilus influenzae, species that were not observed in the calculus from three other individuals. Combined with the presence of incipient endocranial lesions and pronounced meningeal grooves, we interpret this as an ancient case of meningococcal disease. This disease afflicts millions around the globe today, but little is known about its (pre)history. With additional sampling, we suggest NGS of calculus offers an exciting new window into the evolutionary history of these bacterial species and their interactions with humans. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Mexico | 2 | 40% |
Hong Kong | 1 | 20% |
Japan | 1 | 20% |
Unknown | 1 | 20% |
Demographic breakdown
Type | Count | As % |
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Scientists | 3 | 60% |
Members of the public | 2 | 40% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 28% |
Student > Bachelor | 6 | 15% |
Researcher | 4 | 10% |
Student > Master | 4 | 10% |
Professor | 3 | 8% |
Other | 4 | 10% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 8 | 20% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Medicine and Dentistry | 4 | 10% |
Arts and Humanities | 3 | 8% |
Immunology and Microbiology | 2 | 5% |
Other | 4 | 10% |
Unknown | 12 | 30% |