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Attention Score in Context
| Title |
Brain Targeting Delivery Facilitated by Ligand-Functionalized Layered Double Hydroxide Nanoparticles
|
|---|---|
| Published in |
ACS Applied Materials & Interfaces, May 2018
|
| DOI | 10.1021/acsami.8b04613 |
| Pubmed ID | |
| Authors |
Weiyu Chen, Huali Zuo, Enqi Zhang, Li Li, Petra Henrich-Noack, Helen Cooper, Yujin Qian, Zhi Ping Xu |
| Abstract |
A delivery platform with highly selective permeability through blood brain barrier (BBB) is essential for brain disease treatment. In this research, we designed and prepared a novel target nano-platform, i.e. layered double hydroxide nanoparticle (LDH) conjugated with targeting peptide-ligand angiopep2 (Ang2) or rabies virus glycoprotein (RVG) via inter-matrix bovine serum albumin (BSA) for brain targeting. In vitro studies show that functionalization with the target ligand significantly increases the delivery efficiency of LDH nanoparticles to the brain endothelial cells (bEnd.3) and the transcytosis through the simulated BBB model, i.e. bEnd.3 cell-constructed multilayer membrane. In vivo confocal neuroimaging (ICON) of the rat's blood-retina area dynamically demonstrates that LDH nanoparticles modified with peptide ligands have shown a prolonged retention period within the retina vessel in comparison with pristine LDH group. Moreover, Ang2-modified LDH nanoparticles are found to more specifically accumulate in the mouse brain than the control and RGV-modified LDH nanoparticles after 2 and 48 h intravenous injection. All these findings strongly suggest that Ang2-modified LDHs can serve as an effective targeting nano-platform for brain disease treatment. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 37 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 24% |
| Student > Master | 4 | 11% |
| Researcher | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Student > Bachelor | 2 | 5% |
| Other | 3 | 8% |
| Unknown | 13 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 5 | 14% |
| Materials Science | 3 | 8% |
| Veterinary Science and Veterinary Medicine | 2 | 5% |
| Agricultural and Biological Sciences | 2 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 5% |
| Other | 7 | 19% |
| Unknown | 16 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 May 2018.
All research outputs
#18,830,858
of 23,337,345 outputs
Outputs from ACS Applied Materials & Interfaces
#12,274
of 17,948 outputs
Outputs of similar age
#256,662
of 331,525 outputs
Outputs of similar age from ACS Applied Materials & Interfaces
#285
of 416 outputs
Altmetric has tracked 23,337,345 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 17,948 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 331,525 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 12th percentile – i.e., 12% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 416 others from the same source and published within six weeks on either side of this one. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.