Title |
Beyond gut microbiota: understanding obesity and type 2 diabetes
|
---|---|
Published in |
Hormones international journal of endocrinology and metabolism, July 2015
|
DOI | 10.14310/horm.2002.1571 |
Pubmed ID | |
Authors |
Eva Lau, Davide Carvalho, Cidália Pina-Vaz, José-Adelino Barbosa, Paula Freitas |
Abstract |
Obesity and type 2 diabetes are metabolic diseases that have reached epidemic proportions worldwide. Although their etiology is complex, both result from interplay between behaviour, environment and genetic factors. Within ambient determinants, human overall gut bacteria have been identified as a crucial mediator of obesity and its consequences. Gut microbiota plays a crucial role in gastro-intestinal mucosa permeability and regulates the fermentation and absorption of dietary polyssacharides, which may explain its importance in the regulation of fat accumulation and the resultant development of obesity-related diseases. The main objective of this review is to address the pathogenic association between gut microbiota and obesity and to explore related innovative therapeutic targets. New insights into the role of the small bowel and gut microbiota in diabetes and obesity may make possible the development of integrated strategies to prevent and treat these metabolic disorders. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 1 | 14% |
United States | 1 | 14% |
Unknown | 5 | 71% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Indonesia | 1 | <1% |
Spain | 1 | <1% |
Unknown | 183 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 38 | 21% |
Student > Bachelor | 35 | 19% |
Researcher | 21 | 11% |
Student > Ph. D. Student | 16 | 9% |
Student > Postgraduate | 12 | 6% |
Other | 27 | 15% |
Unknown | 36 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 47 | 25% |
Biochemistry, Genetics and Molecular Biology | 24 | 13% |
Nursing and Health Professions | 23 | 12% |
Agricultural and Biological Sciences | 19 | 10% |
Immunology and Microbiology | 9 | 5% |
Other | 21 | 11% |
Unknown | 42 | 23% |