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X Demographics
Mendeley readers
Attention Score in Context
| Title |
AllR Controls the Expression of Streptomyces coelicolor Allantoin Pathway Genes
|
|---|---|
| Published in |
Applied and Environmental Microbiology, July 2015
|
| DOI | 10.1128/aem.02098-15 |
| Pubmed ID | |
| Authors |
Laura Navone, Juan Pablo Macagno, Cuauhtémoc Licona-Cassani, Esteban Marcellin, Lars K. Nielsen, Hugo Gramajo, Eduardo Rodriguez |
| Abstract |
Streptomyces species are native inhabitants of soil, a natural environment where nutrients can be scarce and competition fierce. They have evolved ways to metabolize unusual nutrients such as purines and its derivatives, highly abundant in soil. Catabolism of these uncommon carbon and nitrogen sources needs to be tightly regulated in response to nutrient availability and environmental stimulus. Recently, the allantoin degradation pathway was characterized in S. coelicolor. However, there are questions that remained unanswered, particularly those regarding pathway regulation. Here, using a combination of proteomics and genetic approaches, we identified the negative regulator of the allantoin pathway, AllR. In vitro studies confirmed that AllR binds to the promoter regions of allantoin catabolic genes and determined the AllR DNA binding motif. In addition, effector studies showed that allantoic acid, and glyoxylate, to a lesser extent, inhibit the binding of AllR to the DNA. Inactivation of AllR repressor leads to the constitutive expression of the AllR regulated genes and intriguingly impairs actinorhodin and undecylprodigiosin production. Genetics and proteomics analysis revealed that among all genes from allantoin pathway that are up-regulated in the allR mutant, hyi gene encoding a hydroxypyruvate isomerase (Hyi) is responsible of the impairment of antibiotic production. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 25 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 25 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 8 | 32% |
| Student > Ph. D. Student | 4 | 16% |
| Student > Bachelor | 3 | 12% |
| Professor | 2 | 8% |
| Lecturer | 2 | 8% |
| Other | 3 | 12% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 40% |
| Biochemistry, Genetics and Molecular Biology | 5 | 20% |
| Unspecified | 1 | 4% |
| Nursing and Health Professions | 1 | 4% |
| Sports and Recreations | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 7 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 July 2015.
All research outputs
#20,655,488
of 25,373,627 outputs
Outputs from Applied and Environmental Microbiology
#17,705
of 19,160 outputs
Outputs of similar age
#189,173
of 258,632 outputs
Outputs of similar age from Applied and Environmental Microbiology
#155
of 195 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 19,160 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one is in the 3rd percentile – i.e., 3% of its peers scored the same or lower than it.
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We're also able to compare this research output to 195 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.