Title |
Differential responses of the right ventricle to abnormal loading conditions in mice: pressure vs. volume load
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Published in |
European Journal of Heart Failure, February 2014
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DOI | 10.1093/eurjhf/hfr134 |
Pubmed ID | |
Authors |
Beatrijs Bartelds, Marinus A. Borgdorff, Annemiek Smit‐van Oosten, Janny Takens, Bibiche Boersma, Marcel G. Nederhoff, Nynke J. Elzenga, Wiek H. van Gilst, Leon J. De Windt, Rolf M.F. Berger |
Abstract |
Right ventricular (RV) dysfunction is a major determinant of long-term morbidity and mortality in congenital heart disease. The right ventricle (RV) is genetically different from the left ventricle (LV), but it is unknown as to whether this has consequences for the cellular responses to abnormal loading conditions. In the LV, calcineurin-activation is a major determinant of pathological hypertrophy and an important target for therapeutic strategies. We studied the functional and molecular adaptation of the RV in mouse models of pressure and volume load, focusing on calcineurin-activation. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 1% |
Unknown | 71 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 25% |
Researcher | 9 | 13% |
Student > Master | 8 | 11% |
Other | 7 | 10% |
Professor | 4 | 6% |
Other | 15 | 21% |
Unknown | 11 | 15% |
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Medicine and Dentistry | 39 | 54% |
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Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
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Arts and Humanities | 1 | 1% |
Other | 4 | 6% |
Unknown | 16 | 22% |