↓ Skip to main content

Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax

Overview of attention for article published in Antimicrobial Agents and Chemotherapy, July 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (80th percentile)
  • High Attention Score compared to outputs of the same age and source (86th percentile)

Mentioned by

twitter
4 X users
patent
2 patents

Citations

dimensions_citation
20 Dimensions

Readers on

mendeley
29 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax
Published in
Antimicrobial Agents and Chemotherapy, July 2015
DOI 10.1128/aac.00874-15
Pubmed ID
Authors

Grennady Wirjanata, Boni F. Sebayang, Ferryanto Chalfein, Prayoga, Irene Handayuni, Leily Trianty, Enny Kenangalem, Rintis Noviyanti, Brice Campo, Jeanne Rini Poespoprodjo, Jörg J. Möhrle, Ric N. Price, Jutta Marfurt

Abstract

The 4-aminoquinoline naphthoquine (NQ) and the thiazine dye methylene blue (MB) have potent in vitro efficacy against P. falciparum, but susceptibility data for P. vivax are limited. The species- and stage-specific ex vivo activities of NQ and MB were assessed using a modified schizont maturation assay on clinical field isolates from Papua, Indonesia, where multidrug resistant P. falciparum and P. vivax are prevalent. Both compounds were highly active against P. falciparum (median IC50 of NQ = 8.0 nM [Range: 2.6-71.8 nM] and MB = 1.6 nM [0.2-7.0 nM]) and P. vivax (NQ = 7.8 nM [1.5-34.2] and MB =1.2 nM [0.4-4.3]). Stage-specific drug susceptibility assays revealed significantly greater IC50s in parasites exposed at trophozoite compared to ring stage for NQ in P. falciparum (26.5 versus 5.1 nM, p=0.021) and P. vivax (341.6 versus 6.5 nM, p=0.021), and for MB in P. vivax (10.1 versus 1.6 nM, p=0.010). The excellent ex vivo activity of NQ and MB against both P. falciparum and P. vivax highlights their potential utility for the treatment of multidrug resistant malaria in areas endemic for both species.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Germany 1 3%
Unknown 27 93%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 17%
Student > Doctoral Student 5 17%
Student > Ph. D. Student 4 14%
Student > Master 4 14%
Student > Bachelor 2 7%
Other 5 17%
Unknown 4 14%
Readers by discipline Count As %
Medicine and Dentistry 10 34%
Agricultural and Biological Sciences 4 14%
Biochemistry, Genetics and Molecular Biology 3 10%
Immunology and Microbiology 3 10%
Environmental Science 2 7%
Other 1 3%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2021.
All research outputs
#4,658,834
of 25,371,288 outputs
Outputs from Antimicrobial Agents and Chemotherapy
#3,940
of 15,580 outputs
Outputs of similar age
#53,950
of 275,567 outputs
Outputs of similar age from Antimicrobial Agents and Chemotherapy
#33
of 244 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 15,580 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has gotten more attention than average, scoring higher than 74% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 275,567 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 244 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.